Open Stanford (Montoya) study “Exercise and Immune Profiling in ME/CFS”

I verified with Stanford that it was ok to share with other patients. This Montoya study is on exercise, the human microbiome and ME/CFS, and includes a bicycle exercise tolerance test.

----
Over the past year, there has been growing interest in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
 around the world. An increasing number of scientists and clinicians are engaging in research and practices that have the potential to lead to a greater understanding of the root causes of ME/CFS. I am excited to report that Dr. Jose Montoya’s Stanford ME/CFS Initiative will be joining in a new collaborative research effort with Columbia University to further understand the association between exercise, the human microbiome and ME/CFS.

We are inviting you to participate in a new study entitled “Exercise and Immune Profiling in ME/CFS”. In this study, we will ask you to participate in a baseline screening assessment in our clinic (Location: Stanford University). We will ask you to provide in-depth information about your symptoms and medical conditions in the form of questionnaires, and to undergo a brief physical exam and blood collection; At this time, our team will provide kits for the collection of stool and saliva samples for the next phase of the study, and we will schedule your appointment for a bicycle exercise tolerance test (ETT).

In the next phase, you will be asked to complete two study visits, immediately before and 24-hours after administration of an ETT (Location: Stanford Hospital). You will bring your collected samples (stool and saliva for research purposes) with you, and will undergo blood collections at both visits. You will complete a series of questionnaires at each visit, and at three time points in between.

All procedures conducted under this research study will be free of charge.

Upon completion of each study assessment, sample collection and self-report questionnaires, you will receive reimbursement in a staged fashion. Therefore, you will receive $25 for the pre-ETT visit 2, $50 for the ETT visit and $50 for the post-ETT visit.

If you are interested in participating in this study, please complete the following eligibility survey (Prescreening for ME/CFS Exercise Tolerance Testing Study). If you are not interested in the study or do not wish to participate, please do not be concerned. Your decision will in no way affect the clinical care that you receive at Stanford Hospital & Clinics. If you would like to get in touch with the Clinical Research Coordinator, Tullia Lieb, please email tlieb@stanford.edu

Participant’s rights questions, contact 1-866-680-2906

Sincerely,
Jose Montoya, M.D.

 

You would have thought they would put a description of the bicycle exercise tolerance test (ETT) in the letter, or the link to the questionnaire. Most folks with ME are going to be concerned about the crash following the test and will want to know more details about what the test entails. Perhaps you can feed that back to them @Webdog

 

Good points. I'd suggest directing questions to the email in the letter. As I understand it, Stanford is recruiting patients, but is still working on study procedures.

 

I took up your suggestion @Webdog and here is Tullia's explanation

---------------------------------
The purpose of this study is to evaluate the immune system and microbiome of ME/CFS patients before and then during a post exertional malaise episode. PEM is one of the hallmark symptoms of ME/CFS and there has not been a ton of work done trying to figure out what exactly is going on.
The exercise test that we are using is able to evaluate cardiovascular function and how well your body is able to use oxygen.
Here's a brief description of the test: https://med.virginia.edu/exercise-p...ment-for-community-members-2/vo2-max-testing/

We understand that exercise is difficult for most, if not all ME/CFS patients, and we do not advise patients to participate without first weighing the pros and cons to their health. We are happy to speak with patients individually to help assess their participation.

VO2 Max Testing - UVA
The Exercise Physiology Core lab is pleased to offer the fitness and body composition services listed below to members of the community. These are precise measurements of fitness levels, as opposed to indirect or estimated measures that are available elsewhere.
med.virginia.edu

I did the test myself, and my experience was around ten minutes long, but you can stop whenever you feel like you cannot keep up with the pace.

I hope this answers some of your questions. Let me know.

P.S. we do not condone graded exercise therapy as a treatment for CFS. If anything, we try to encourage patients to minimize the number of PEM episodes they have.

Tullia Lieb
Clinical Research Coordinator
T: (650)-723-8126
email: tlieb@stanford.edu

 

Some extra clarification from Stanford
1) The bicycle challenge is only on one day. The second day, patients come in for a blood draw.
2) The cardiologist is willing to write up a short report with the VO2 max for the patient who participates.

 

I would be curious to know whether microbiome composition would change in the subsequent days following the exercise rather than only 24 hours after. My rationale is that some people will not have any bowel movement 24 hours especially if they are travelling for this test as travel and stress can change bowel habits.

Then I wonder whether colonies (is that the right term?) or composition of the microbiome changes according to where the stool is located, whether it is in the colon or in the small bowel at the time of exercise and collection, and whether this changes in the several hours amd days following the exercise test.

That would be an interesting study.

Lastly, the amount awarded to the patient is minimal, and sadly i am reminded of a certain researcher who was conducting psychological studies that were rewarding 600$ per patient. I really wish patients were awarded substantial amount of money to submit to an exercise test that will set them back for weeks or months.

This said I am not adverse to the study, in fact I welcome it.