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Small-Molecule Inhibition of Glucose Transporters GLUT-1-4, 2020, Reckzeh & Waldmann

Discussion in 'Other health news and research' started by SNT Gatchaman, May 9, 2022.

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  1. SNT Gatchaman

    SNT Gatchaman Senior Member (Voting Rights)

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    Small-Molecule Inhibition of Glucose Transporters GLUT-1-4
    Elena S Reckzeh, Herbert Waldmann

    Glucose addiction is observed in cancer and other diseases that are associated with hyperproliferation. The development of compounds that restrict glucose supply and decrease glycolysis has great potential for the development of new therapeutic approaches. Addressing facilitative glucose transporters (GLUTs), which are often upregulated in glucose-dependent cells, is therefore of particular interest. This article reviews a selection of potent, isoform-selective GLUT inhibitors and their biological characterization. Potential therapeutic applications of GLUT inhibitors in oncology and other diseases that are linked to glucose addiction are discussed.

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    SNT Gatchaman, May 9, 2022
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    MEMarge and Peter Trewhitt like this.
  2. SNT Gatchaman

    SNT Gatchaman Senior Member (Voting Rights)

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    Detailed review article, posted for background on cellular fuel starvation as a potential mechanism in ME energy impairment.

     
    SNT Gatchaman, May 9, 2022
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    alktipping, Mij, MEMarge and 2 others like this.

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