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Skeletal muscle alterations in patients with acute Covid-19 and post-acute sequelae of Covid-19, 2021, Soares et al

Discussion in 'Long Covid research' started by ola_cohn, Dec 5, 2021.

  1. ola_cohn

    ola_cohn Established Member (Voting Rights)

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    90
    Location:
    Australia
    Abstract
    Background and methods

    Skeletal muscle-related symptoms are common in both acute Covid-19 and Post-Acute Sequelae of Covid-19 (PASC). In this narrative review, we discuss cellular and molecular pathways that are affected, and consider these in regard to skeletal muscle involvement in other conditions, such as acute respiratory distress syndrome, critical illness myopathy and post-viral fatigue syndrome.

    Results
    Patients with severe Covid-19 and PASC suffer from skeletal muscle weakness and exercise intolerance. Histological sections present muscle fiber atrophy, metabolic alterations, and immune cell infiltration. Contributing factors to weakness and fatigue in patients with severe Covid-19 include systemic inflammation, disuse, hypoxemia, and malnutrition. These factors also contribute to post-ICU syndrome and ICU-acquired weakness, and likely explain a substantial part of Covid-19-acquired weakness. The skeletal muscle weakness and exercise intolerance associated with PASC are more obscure and different factors likely contribute. Direct SARS-CoV-2 viral infiltration into skeletal muscle or an aberrant immune system likely contribute. Similarities between skeletal muscle alterations in PASC and chronic fatigue syndrome deserve further study.

    Conclusion
    Both SARS-CoV-2 specific factors and generic consequences of acute disease likely underlie the observed skeletal muscle alterations in both acute Covid 19 and PASC.

    https://www.repository.cam.ac.uk/handle/1810/331064
     
    Rosie, Yvonne, hibiscuswahine and 7 others like this.

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