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Severity of neurological long-COVID symptoms correlates with increased level of autoantibodies targeting vasoregulatory and autonomic.., 2023, Seibert

Discussion in 'Long Covid research' started by EndME, Sep 10, 2023.

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  1. EndME

    EndME Senior Member (Voting Rights)

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    895
    Severity of neurological long-COVID symptoms correlates with increased level of autoantibodies targeting vasoregulatory and autonomic nervous system receptors

    Abstract
    Background
    The Long-COVID syndrome constitutes a plethora of persisting symptoms with neurological disorders being the most disabling ones. The pathogenesis of Long-COVID is currently under heavy scrutiny and existing data on the role of auto-immune reaction to G-protein coupled receptors (GPCR) are conflicting.

    Methods
    This monocentric, cross-sectional study included patients who suffered a mild to moderate SARS-CoV-2 infection up to 12 months prior to enrollment with (n = 72) or without (n = 58) Long-COVID diagnosis according to the German S1 guideline or with no known history of SARS-CoV-2 infection (n = 70). While autoantibodies towards the vasoregulation associated Adrenergic Receptor (ADR) B1 and B2 and the CNS and vasoregulation associated muscarinic acetylcholine receptor (CHR) M3 and M4 were measured by ELISA, neurological disorders were quantified by internationally standardized questionnaires.

    Results
    The prevalence and concentrations of evaluated autoantibodes were significantly higher in Long-COVID compared to the 2 other groups (p = 2.1*10−9) with a significantly higher number of patients with simultaneous detection of more than one autoantibody in Long-COVID group (p = 0.0419). Importantly, the overall inflammatory state was low in all 3 groups. ARB1 and ARB2 correlated negatively CERAD Trail Marking A and B (R ≤ −0.26, p ≤ 0.043), while CHRM3 correlated positively with Chadler Fatigue Scale (R = 0.37, p = 0.0087).

    Conclusions
    Concentrations of autoantibodies correlates to intensity of neurological disorders including psychomotor speed, visual search, attention, and fatigue.

    https://www.sciencedirect.com/science/article/abs/pii/S1568997223001799
     
    EndME, Sep 10, 2023
    #1
    MEMarge, livinglighter, DokaGirl and 6 others like this.
  2. Hutan

    Hutan Moderator Staff Member

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    27,092
    Location:
    Aotearoa New Zealand
    A German team: Hölkeskampring

    From the introduction:
    So, they are hypothesising that the lack of good evidence for autoantibodies in Long covid so far might be because the auto antibodies are being bound in tissue, rather than floating around in the blood. They suggest that inflammatory state might make this happen.

    Unfortunately the paper is not open access, so I haven't read the paper. But it doesn't sound as though they found evidence of an inflammatory state. And yet it does sound as though they found evidence for higher levels of autoantibodies, in blood.

    It sounds to me as though more work needs to be done at the tissue level to prove or disprove this hypothesis about autoantibodies in Long covid.
     
    Hutan, Sep 10, 2023
    #2
    DokaGirl, Sean, Michelle and 4 others like this.
  3. rvallee

    rvallee Senior Member (Voting Rights)

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    Location:
    Canada
    sigh
     
    rvallee, Sep 10, 2023
    #3
    RedFox, DokaGirl, alktipping and 1 other person like this.
  4. Jonathan Edwards

    Jonathan Edwards Senior Member (Voting Rights)

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    Location:
    London, UK
    That is what is known as clutching at straws.
     
    Jonathan Edwards, Sep 10, 2023
    #4
    FMMM1, RedFox, obeat and 7 others like this.
  5. MEMarge

    MEMarge Senior Member (Voting Rights)

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    Location:
    UK
    Once again the useless Chalder Fatigue Scale appears
     
    MEMarge, Sep 11, 2023
    #5
    FMMM1, Ash and RedFox like this.

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