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Scientists discover promising ‘off-switch’ for inflammatory diseases

Discussion in 'BioMedical ME/CFS News' started by Mattie, Mar 29, 2018.

  1. Mattie

    Mattie Senior Member (Voting Rights)

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  2. Sly Saint

    Sly Saint Senior Member (Voting Rights)

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    "
    A critical finding was to show itaconate switched off an over-active immune system in mice.

    “It’s well known that macrophages cause inflammation, but we have just found they can be coaxed to make a biochemical called itaconate. This functions as an important brake, or off switch, on the macrophage, cooling the heat of inflammation in a process never before described,” Prof O’Neill said.

    Itaconate
    Dr Evanna Mills, who with PhD student Dylan Ryan is the joint first author of the work, said: “The macrophage takes the nutrient glucose, whose day job it is to provide energy, and surprisingly turns it into itaconate. This then blocks production of inflammatory factors, and also protects mice from the lethal inflammation that can occur during infection.”"

    interesting
     
  3. Trish

    Trish Moderator Staff Member

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    From the article:

    Paper the article is based on is in Nature this week. Note that the research was done on mice:

    Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 Evanna L. Mills et al.

    https://www.nature.com/articles/nature25986
     

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