1. Sign our petition calling on Cochrane to withdraw their review of Exercise Therapy for CFS here.
    Dismiss Notice
  2. Guest, the 'News in Brief' for the week beginning 8th April 2024 is here.
    Dismiss Notice
  3. Welcome! To read the Core Purpose and Values of our forum, click here.
    Dismiss Notice

RNaseL

Discussion in 'ME/CFS research news' started by wastwater, Jul 16, 2019.

Tags:
  1. wastwater

    wastwater Senior Member (Voting Rights)

    Messages:
    347
    What happened to RNaseL it was mentioned as a potential bio marker in earlier work
     
    wastwater, Jul 16, 2019
    #1
    Annamaria, ladycatlover, Robert 1973 and 1 other person like this.
  2. Trish

    Trish Moderator Staff Member

    Messages:
    52,225
    Location:
    UK
    @wastwater, are you able to link to some of the research you refer to. My memory is not up to it!
     
    Trish, Jul 16, 2019
    #2
    wastwater, Annamaria and ladycatlover like this.
  3. ME/CFS Skeptic

    ME/CFS Skeptic Senior Member (Voting Rights)

    Messages:
    3,507
    Location:
    Belgium
    Good question. Here in Belgium, De Meirleir was involved and made a diagnostic test about it. It was a big deal around 15 years ago. My guess is that somebody showed that these tests were unreliable, but I can't find the study that did that.

    Here are some of the studies:

    Suhadolnik et al. 1994. Upregulation of the 2-5A synthetase/RNase L antiviral pathway associated with chronic fatigue syndrome.

    Suhadolnik et al. 1997. Biochemical evidence for a novel low molecular weight 2-5A-dependent RNase L in chronic fatigue syndrome.

    Nijs & De Meirleir, 2005. Impairments of the 2-5A synthetase/RNase L pathway in chronic fatigue syndrome.
     
    ME/CFS Skeptic, Jul 16, 2019
    #3
    MarcNotMark, wastwater, Annamaria and 5 others like this.
  4. Mithriel

    Mithriel Senior Member (Voting Rights)

    Messages:
    2,816
    It is never safe to assume that with ME, Michiel :) Over the years things keep getting rediscovered and it is very frustrating. Researchers leave the field or retire and no one picks up their work.
     
    Mithriel, Jul 16, 2019
    #4
    MarcNotMark, wastwater, Medfeb and 7 others like this.

Share This Page