Review of Vitamins and Supplements in Multiple Sclerosis

Webdog · May 28, 2018

A review of vitamins and dietary supplements by patients with Multiple Sclerosis found that the only "vitamin" with sufficient evidence to support supplementation was Vitamin D.

Use of Vitamins and Dietary Supplements by Patients With Multiple Sclerosis: A Review
https://jamanetwork.com/journals/jamaneurology/article-abstract/2679039

The article is paywalled, but Neurology Advisor has a summary of the supplements evaluated, and findings (spacing and bolding mine):

https://www.neurologyadvisor.com/mu...or/vitamin-supplement-diet-ms/article/765464/

Neurology Advisor said:

Vitamin A was associated with decreased interleukin 17, T-bet, retinoic acid-related orphan receptor gamma t (RORγt), and interferon gamma (IFN-γ), as well as increased transforming growth factor beta 1 and forkhead box protein P3 and an improvement in fatigue.

Vitamin B1 was linked with reduced fatigue.

Vitamin B7 correlated with improved visual sharpness, muscular strength, energy levels, visual evoked potentials, mood, and motor coordination.

Vitamin D was associated with a lower relapse rate and fewer MRI-detected lesions.

Vitamin B12 treatment correlated negatively with visual evoked potentials.

Of these, only vitamin D's associations were found to be significant enough to merit clinical application.

Vitamins B2, B3, B5, B6, B9, C, and E showed no effects on individuals with MS.

Of dietary supplements, creatine, curcumin, green tea extract, and resveratrol showed no effect in subjects with MS.

Caffeine, carnitine, coenzyme Q10, ginkgo biloba, lipoic acid, polyunsaturated fatty acids, and probiotics showed some effects, but none were significant.
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adambeyoncelowe · May 28, 2018

Very interesting.

Webdog · May 31, 2018

Association Between Vitamin D Supplementation, Multiple Sclerosis Relapse Still Unclear
https://www.neurologyadvisor.com/cm...-to-vitamin-d-supplementation/article/769199/

Neurology Advisor said:

Vitamin D supplementation may reduce the risk of relapse among patients with multiple sclerosis (MS), according to a study presented at the 2018 Annual Meeting of the Consortium of Multiple Sclerosis Centers, held May 30-June 2 in Nashville, Tennessee.
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Neurology Advisor said:

Although the study demonstrated a lower relapse rate among patients with MS who supplemented their diet with vitamin D, the analysis did not reach statistical significance. This finding precludes the ability to determine the wide-scale applicability of vitamin D supplementation in the MS population.
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Review of Vitamins and Supplements in Multiple Sclerosis

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