Tom Kindlon
Senior Member (Voting Rights)
Free fulltext:
https://urfpublishers.com/open-access/research-insights-to-long-covid.pdf
Journal
Journal of Advanced Biomedical Engineering
Publication date
2023-07-20
Keywords
Long-COVID, post-acute Covid-19 syndrome, post-infectious syndromes, chronic fatigue syndrome, brain fog, immunoadsorption, autoimmunity, endothelial dysfunction, mitochondrial dysfunction, clinical trials
Authors
Werner CG, Sittner W, Wagner FD
Abstract
When 2019 the world community was unexpectedly overrun by a new coronavirus called SARS-CoV-2, the acute symptom-oriented treatment of the patients concerned as well as the containment of the virus-spread were in the foreground of activities. The underlying mechanism(s) of the diverse organ infestations was unclear and is still subject of research today. The first emerging virus variant was very aggressive and caused organ failure resulting in deaths, too many deaths.
Three years later, we are facing a multifaceted population that has been completely or partially vaccinated, experienced the illness one or more times or never had contact with the virus. Apparently the clinic copes with the acute symptoms of the infection today, the currently circulating virus variants seem to be more harmless. However, the initial concern that infection with the SARS-CoV-2 virus may lead to sustained or recurrent multi-organ symptoms and even failures is becoming more and more evident. Many patients experience extended COVID-19 symptomatology over weeks to months that is called post-acute COVID-19 syndrome or more commonly as Long-COVID.
There is currently no approved drug for the treatment of Long-COVID: The research for Long-COVID treatments has started mostly with small pilot studies, observations or case reports, mainly using marketed products to improve clinical symptoms of Long-COVID that are common in similar conditions such as the post-infectious myalgic-encephalomyelitis/chronic fatigue syndrome (ME/CFS). However, more targeted interventions for Long-COVID based on evidence in controlled clinical trials are urgently required.
In this Review we discuss the current knowledge on Long-COVID. We describe how the pharmaceutical industry, medical device companies as well as academic research are now increasing their efforts to gain knowledge of risk factors and pathogenic triggers of Long-COVID with the scope to develop efficient and safe medicines to prevent and /or treat this burdensome disease.
https://urfpublishers.com/open-access/research-insights-to-long-covid.pdf
Journal
Journal of Advanced Biomedical Engineering
Publication date
2023-07-20
Keywords
Long-COVID, post-acute Covid-19 syndrome, post-infectious syndromes, chronic fatigue syndrome, brain fog, immunoadsorption, autoimmunity, endothelial dysfunction, mitochondrial dysfunction, clinical trials
Authors
Werner CG, Sittner W, Wagner FD
Abstract
When 2019 the world community was unexpectedly overrun by a new coronavirus called SARS-CoV-2, the acute symptom-oriented treatment of the patients concerned as well as the containment of the virus-spread were in the foreground of activities. The underlying mechanism(s) of the diverse organ infestations was unclear and is still subject of research today. The first emerging virus variant was very aggressive and caused organ failure resulting in deaths, too many deaths.
Three years later, we are facing a multifaceted population that has been completely or partially vaccinated, experienced the illness one or more times or never had contact with the virus. Apparently the clinic copes with the acute symptoms of the infection today, the currently circulating virus variants seem to be more harmless. However, the initial concern that infection with the SARS-CoV-2 virus may lead to sustained or recurrent multi-organ symptoms and even failures is becoming more and more evident. Many patients experience extended COVID-19 symptomatology over weeks to months that is called post-acute COVID-19 syndrome or more commonly as Long-COVID.
There is currently no approved drug for the treatment of Long-COVID: The research for Long-COVID treatments has started mostly with small pilot studies, observations or case reports, mainly using marketed products to improve clinical symptoms of Long-COVID that are common in similar conditions such as the post-infectious myalgic-encephalomyelitis/chronic fatigue syndrome (ME/CFS). However, more targeted interventions for Long-COVID based on evidence in controlled clinical trials are urgently required.
In this Review we discuss the current knowledge on Long-COVID. We describe how the pharmaceutical industry, medical device companies as well as academic research are now increasing their efforts to gain knowledge of risk factors and pathogenic triggers of Long-COVID with the scope to develop efficient and safe medicines to prevent and /or treat this burdensome disease.
