Research in progress: A Unified Mechanism for Functional Neurological Symptoms, 2015 to 2018, Edwards et al

Andy · Feb 22, 2018

Searching on the project reference, MR/M02363X/1, gives me the following results:

https://www.sciencedirect.com/science/article/pii/B9780128017722000126 - "Chapter 12 - Neurobiologic theories of functional neurologic disorders"

http://jnnp.bmj.com/content/88/2/190 - "Spectral power changes prior to psychogenic non-epileptic seizures: a pilot study"

Does this mean he's published already? I can't access Sci Hub so I can't get past the paywalls on them to figure it out.

Andy · Feb 22, 2018

Also just found this as well, http://europepmc.org/abstract/MED/27694498 - "Randomised feasibility study of physiotherapy for patients with functional motor symptoms"

Abstract
Objective To determine the feasibility of conducting a randomised controlled trial of a specialist physiotherapy intervention for functional motor symptoms (FMS).

Methods A randomised feasibility study was conducted recruiting patients with a clinically established diagnosis of FMS from a tertiary neurology clinic in London, UK. Participants were randomised to the intervention or a treatment as usual control. Measures of feasibility and clinical outcome were collected and assessed at 6 months.

Results 60 individuals were recruited over a 9-month period. Three withdrew, leaving 29 intervention and 28 controls participants in the final analysis. 32% of patients with FMS met the inclusion criteria, of which 90% enrolled. Acceptability of the intervention was high and there were no adverse events. At 6 months, 72% of the intervention group rated their symptoms as improved, compared to 18% in the control group. There was a moderate to large treatment effect across a range of outcomes, including three of eight Short Form 36 (SF36) domains (d=0.46–0.79). The SF36 Physical function was found to be a suitable primary outcome measure for a future trial; adjusted mean difference 19.8 (95% CI 10.2 to 29.5). The additional quality adjusted life years (QALY) with intervention was 0.08 (95% CI 0.03 to 0.13), the mean incremental cost per QALY gained was £12 087.

Conclusions This feasibility study demonstrated high rates of recruitment, retention and acceptability. Clinical effect size was moderate to large with high probability of being cost-effective. A randomised controlled trial is needed.
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Valentijn · Feb 22, 2018

Andy said: ↑

http://jnnp.bmj.com/content/88/2/190 - "Spectral power changes prior to psychogenic non-epileptic seizures: a pilot study"

Does this mean he's published already? I can't access Sci Hub so I can't get past the paywalls on them to figure it out.
Click to expand...

http://sci-hub.tw/http://dx.doi.org/10.1136/jnnp-2016-314080

It's a case study involving 3 patients, without much more detail than is in the abstract.

Technical details of study funding and such are at the end:

Contributors: AMM, IP and MJE designed the study, AMM and IP conducted the study. AMM, MB and SL performed the analyses. AMM wrote the first draft, which was reviewed by all coauthors. AMM is the guarantor and accepts full responsibility for the work and/or the conduct of the study, had access to the data and controlled the decision to publish.

Funding: Institutional (Sobell Department of Motor Neuroscience and Movement Disorders, University College London, UCL).

Competing interests: None declared.

Patient consent: Obtained.

Ethics approval: UCL.

Provenance and peer review Not commissioned; externally peer reviewed.
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TiredSam · Feb 22, 2018

We believe that fatigue in chronic fatigue syndrome may occur because of abnormal activation of a network of structures in the brain that are usually involved in signalling the presence of infection and inflammation in the body and which give rise to a common set of symptoms experienced by everyone (and indeed across species)
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What on earth are we going to be compared to next? I don't mind Naviaux comparing me to a nematode worm but I won't have Mark Edwards and his mates getting cheeky.

Amw66 · Feb 23, 2018

If only we had someone replicating/ loolong into the line of Jared Younger' s work

https://solvecfs.org/2016-ramsay-research-team-1-update/

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Research in progress: A Unified Mechanism for Functional Neurological Symptoms, 2015 to 2018, Edwards et al

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Research in progress: A Unified Mechanism for Functional Neurological Symptoms, 2015 to 2018, Edwards et al

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