Relationships among neurotransmitters, cytokines and cognitive performance with hepatitis C, 2019, Younossi et al

Andy · Aug 25, 2019

Highlights

* Relationships between cognitive performance and serum analytes are different pre-and post-HCV treatment.
* Visual memory (both immediate and delayed) correlates with kynurenine and TGF-B pre-treatment.
* Post-treatment, visual memory correlates with TGF-B while delayed visual memory correlates with GABA.
* Ten individuals improved working memory scores to a minimal clinically important difference.
* Those who improved in working memory had higher baseline levels of TNF and lower baseline levels of COMT.

Abstract
An important extrahepatic consequence of Hepatitis C is its adverse impact on the central nervous system and cognitive performance. We aimed to determine whether there is a significant relationship between selected neurotransmitters and cytokines and cognitive performance in patients with Chronic Hepatitis C before and after achieving sustained virologic response (SVR). Pre-SVR, elevated kynurenine was associated with increased immediate and delayed visual memory, whereas post-SVR the positive associations are between kynurenine and immediate and delayed verbal memory. TGF-B was consistently negatively associated with both immediate and delayed visual memory pre- and post-SVR. These concomitant changes may have important clinical relevance.
Click to expand...

Paywall, https://www.jni-journal.com/article/S0165-5728(19)30325-X/fulltext
Sci hub, not available

Log in or Sign up

Relationships among neurotransmitters, cytokines and cognitive performance with hepatitis C, 2019, Younossi et al

Andy Committee Member

Share This Page

Log in or Sign up

Relationships among neurotransmitters, cytokines and cognitive performance with hepatitis C, 2019, Younossi et al

Andy Committee Member

Share This Page

Useful Searches