Recovery from Myalgic Encephalomyelitis/Chronic Fatigue syndrome developed after [SARS-CoV-2] vaccination: A case report, 2025, Kurotori et al

Recovery from Myalgic Encephalomyelitis/Chronic Fatigue syndrome developed after severe acute respiratory syndrome coronavirus 2 vaccination: A case report

Isaku Kurotori, Wataru Sasao, Masahiko Abe

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Background
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a neurological adverse effect after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccinations. However, clinicians do not recognize the condition well, and no case report has shown a full recovery.

Case Presentation
We present a 65-year-old Japanese female who experienced severe fatigue, postexertional malaise, orthostatic intolerance, and various symptoms after her third SARS-CoV-2 vaccination. Following thorough examinations and excluding other potential diagnoses, she met the diagnostic criteria for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

The symptoms persisted for 30 months and improved ultimately with comprehensive treatment and a self-management strategy, including pacing management, pharmacological treatments, and psychiatric interventions to support those struggling with the despair over the devastating symptoms.

Conclusion
This case report describes ME/CFS following the SARS-CoV-2 vaccination and its full recovery. It illustrates the importance of considering the differential diagnosis of psychiatric disorders and addressing the condition through psychiatric interventions. Our findings provide new insights into treating ME/CFS and the vaccination-related adverse effects.

Link | PDF (Psychiatry and Clinical Neurosciences Reports) [Open Access]

 

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The classic paternalistic approach of telling the patients how to behave and think.

If only I had not been committed to being sick, I would have already recovered!

No, pacing is not a therapy strategy. And there is no collaboration!

Again, there is no mutual decision-making here. Stop trying to micro manage patients.

There is nothing new here.

This appears to be a fortunate case of natural recovery over 2-3 years where the therapist believes that their divine insight and intervention, and the patients focus on recovery, made the recovery happen.

 

Yes, this very much sounds like a natural remission. It remains to be seen whether it is a long-term remission.