Recent advances in our understanding of mast cell activation - or should it be mast cell mediator disorders?, 2019, Theoharides et al

[Andy]

Abstract
Introduction: An increasing number of patients present with multiple symptoms affecting many organs including the brain due to multiple mediators released by mast cells. These unique tissue immune cells are critical for allergic reactions triggered by IgE, but are also stimulated (not activated) by immune, drug, environmental, food, infectious, and stress triggers, leading to secretion of multiple mediators often without histamine and tryptase. The presentation, diagnosis and management of the spectrum of mast cell disorders is very confusing. As a result, specialists have recently excluded neuropsychiatric symptoms, and made the diagnostic criteria stricter, at the expense of excluding most patients.

Areas covered: A literature search was performed on papers published between January 1990 and November 2018 using MEDLINE. Terms used were activation, antihistamines, atopy, autism, brain fog, heparin, KIT mutation, IgE, inflammation, IL-6, IL-31, IL-37, luteolin, mast cells, mastocytosis, mediators, myalgic encephalomyelitis/chronic fatigue syndrome, mycotoxins, release, secretion, tetramethoxyluteolin, tryptase.

Expert commentary: Conditions associated with elevated serum or urine levels of any mast cell mediator, in the absence of any comorbidity that could otherwise explain such increases, should be considered mast cell activation disorders, or better yet be collectively termed “Mast Cell Mediator Disorders (MCMD)”. Emphasis should be placed on the identification of unique mast cell mediators, and development of drugs or supplements that inhibit their release.

Paywalled at https://www.tandfonline.com/doi/abs/10.1080/1744666X.2019.1596800?journalCode=ierm20
Alt at https://sci-hub.se/https://www.tand...1080/1744666X.2019.1596800?journalCode=ierm20

 

[wigglethemouse]

Thanks @Andy. I enjoy reading papers, articles, videos by Theoharis C. Theoharides. Mast Cells are such a fascinating area in our disease.

I am impressed how you find all these papers and appreciate the hard work you do making us aware of them.

 

[Andy]

Thanks @Andy. I enjoy reading papers, articles, videos by Theoharis C. Theoharides. Mast Cells are such a fascinating area in our disease.

I am impressed how you find all these papers and appreciate the hard work you do making us aware of them.

Thanks.

It's less work than it might appear to be, I discovered http://pubcrawler.gen.tcd.ie/, which can be set up to deliver a report on new publications that match certain key words. I've got it set up to run this for me every Saturday, hence why I go on a mini posting binge every Saturday morning.

 

[mango]

Thanks.

It's less work than it might appear to be, I discovered http://pubcrawler.gen.tcd.ie/, which can be set up to deliver a report on new publications that match certain key words. I've got it set up to run this for me every Saturday, hence why I go on a mini posting binge every Saturday morning.

https://www.storkapp.me/ is brilliant too