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Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome, 2018, Verne et al

Discussion in 'Health News and Research unrelated to ME/CFS' started by Tom Kindlon, Aug 27, 2018.

  1. Tom Kindlon

    Tom Kindlon Senior Member (Voting Rights)

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  2. Tom Kindlon

    Tom Kindlon Senior Member (Voting Rights)

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  3. Lisa108

    Lisa108 Senior Member (Voting Rights)

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    The dosis of glutamine in the study was 5g three times a day.
     
  4. Jaybee00

    Jaybee00 Senior Member (Voting Rights)

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    Was it any particular type of glutamine?

    Thanks

    (Don’t have access to article)
     
  5. Trish

    Trish Moderator Staff Member

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    So it looks like it's a treatment for the specific circumstances of diarrhoea following enteric infection, not a general treatment for IBS.
     
  6. Jenny TipsforME

    Jenny TipsforME Senior Member (Voting Rights)

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    As an aside I’m trying out the Low Fodmap diet. Digestive pain was getting so intense I was starting to skip meals/ need liquid food. During the elimination phase the intense, inflammation style pain went and I felt like I slept more deeply. I’m now doing the reintroduction phase. I’ll write about this in more depth sometime.
     
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  7. Andy

    Andy Committee Member & Outreach

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  8. Arnie Pye

    Arnie Pye Senior Member (Voting Rights)

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    Some years ago I took L-Glutamine powder to try and reduce inflammation and pain in my gut. I was taking a lower dose than suggested in this trial. I took it for months and it seemed to help a lot. Then I started getting horrendous pain and cramps - much worse than I had before starting the L-Glutamine. Stopping the powder returned things to "normal for me".

    I think the L-Glutamine was very helpful in the early months and I would take it again. But I wouldn't take it continuously. I would build in regular breaks. But this is just hypothetical - I haven't started taking it again since it caused me so much pain.
     
  9. MeSci

    MeSci Senior Member (Voting Rights)

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    I've experimentally started taking just 5 mg l-glutamine every other day. On the days that I have taken it, I started feeling much more lively and clear-headed about 2-3 hours after taking it, and this lasted all evening (I took it late morning). On the day in-between, I felt muddle-headed and really weird, as has become common in the last few weeks.

    If this continues, I will re-commence taking 5 mg every day, and see what happens.

    I was taking it when I had my 'funny turn' in March 2016, after which I haven't really improved. Maybe this will make a difference...?
     
    Last edited: Oct 11, 2018
  10. MeSci

    MeSci Senior Member (Voting Rights)

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    On looking back through my diaries (I'm not very good at this at present), I found that I have taken it once a day at times since I had my 'turn', but I'm sure that it is more complex than that how often and when it should be taken.

    So as I'm rather less with-it today than on the days that I have taken it, I will start taking it once a day from tomorrow and just see what happens.

    It has been so refreshing to have a clear head when I have taken it!
     

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