Post-COVID Syndrome: An Insight on Its Pathogenesis, 2021, Maltezou et al

I'm not sure whether or not this is worth its own thread

https://www.mdpi.com/2076-393X/9/5/497

Open Access Review
Post-COVID Syndrome: An Insight on Its Pathogenesis
by
Helena C. Maltezou
1,*,

Androula Pavli
2 and

Athanasios Tsakris
3


1 Directorate of Research, Studies and Documentation, National Public Health Organization, 11523 Athens, Greece
2 Department of Travel Medicine, National Public Health Organization, 11523 Athens, Greece
3 Department of Microbiology, Medical School, National and Kapodistrian University of Athens, 15772 Athens, Greece
*
Author to whom correspondence should be addressed.

Academic Editor: Luis Martinez-Sobrido
Vaccines 2021, 9(5), 497; https://doi.org/10.3390/vaccines9050497

Received: 25 April 2021 / Revised: 8 May 2021 / Accepted: 10 May 2021 / Published: 12 May 2021

(This article belongs to the Section COVID-19 Vaccines and Vaccination)

Abstract
Post-COVID syndrome is increasingly recognized as a new clinical entity in the context of SARS-CoV-2 infection. Symptoms persisting for more than three weeks after the diagnosis of COVID-19 characterize the post-COVID syndrome. Its incidence ranges from 10% to 35%, however, rates as high as 85% have been reported among patients with a history of hospitalization. Currently, there is no consensus on the classification of post-COVID syndrome. We reviewed the published information on post-COVID syndrome, putting emphasis on its pathogenesis. The pathogenesis of post-COVID syndrome is multi-factorial and more than one mechanism may be implicated in several clinical manifestations. Prolonged inflammation has a key role in its pathogenesis and may account for some neurological complications, cognitive dysfunction, and several other symptoms. A multisystem inflammatory syndrome in adults (MIS-A) of all ages has been also described recently, similarly to multisystem inflammatory syndrome in children (MIS-C). The post-infectious inflammatory pathogenetic mechanism of MIS-A is supported by the fact that its diagnosis is established through serology in up to one third of cases. Other pathogenetic mechanisms that are implicated in post-COVID syndrome include immune-mediated vascular dysfunction, thromboembolism, and nervous system dysfunction. Although the current data are indicating that the overwhelming majority of patients with post-COVID syndrome have a good prognosis, registries to actively follow them are needed in order to define the full clinical spectrum and its long-term outcome. A consensus-based classification of post-COVID syndrome is essential to guide clinical, diagnostic, and therapeutic management. Further research is also imperative to elucidate the pathogenesis of post-COVID syndrome.

Keywords: COVID-19; SARS-CoV-2; inflammation; post-infectious; complications; long term; pathogenesis

 

None of this is particularly insightful, but I guess the narrative review could be useful for anyone unfamiliar with the field.

The lack of discussion of parallels with ME, CFS and other post-viral syndromes is indicative of the lack of broader picture thinking...