So the 'worsener' / failed responder is interesting. It's this one with the bad clinical scores a year out:
View attachment 32270
This also happens to be the 'responder' with the most yellow dots - ie this person got a whole 'new set' of autoantibodies induced by the therapy. So that would totally fit with them being 'ok before' and 'not so ok after' - they don't look as bad on pre post autoab delta as they dont really have 'more autoabs' post therapy - but they have very different ones.
It looks like Dara wipe out this person's autoantibodies - and worse ones (for them at least) took their place. Immune reset doesn't mean things get better necessarily...
View attachment 32269
