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Pioglitazone improves skeletal muscle functions in reserpine-induced fibromyalgia rat model, 2021, Hassan et al

Discussion in 'Fibromyalgia and Connective Tissue Disorders' started by Andy, Jul 9, 2021.

  1. Andy

    Andy Committee Member (& Outreach when energy allows)

    Messages:
    14,739
    Location:
    Hampshire, UK
    Abstract

    Background

    Fibromyalgia (FM) is characterized by musculoskeletal pain, fatigue, sleep and memory disturbance. There is no definitive cure yet for FM-related health problems. Peroxisome proliferator-activated receptor’s (PPAR’s) activation is associated with insulin sensitisation and improved glucose metabolism. PPAR-γ was reported to alleviate FM allodynia. Limited data are discussing its effect on motor disorders.

    Objective
    To investigate the potential effect of PPAR-γ agonists (pioglitazone, as one member of thiazolidinediones (TZD)) on motor dysfunction in reserpine-induced FM in a rat model.

    Materials and methods
    Thirty-six male Wistar rats were divided into negative control (n = 9) and reserpine-induced FM (n = 27) groups. The latter was subdivided into three equal subgroups (n = 9), positive control (untreated FM model), pioglitazone-treated and GW9662-treated. We evaluated muscle functions and activity of chloramphenicol acetyltransferase, superoxide dismutase, malondialdehyde, and serum levels of interleukin-8 and monocyte chemoattractant protein-1.

    Results
    Pioglitazone significantly relieved fatigue, improved muscle performance, reduced inflammatory cytokines and enhanced antioxidant’s activity, while GW9662, a known PPAR-γ antagonist, aggravated the FM manifestations in the rat model.

    Conclusion
    PPAR-γ agonists show a promising role against FM-associated motor dysfunctions.

    Open access, https://www.tandfonline.com/doi/full/10.1080/07853890.2021.1916069
     
    Peter Trewhitt likes this.
  2. Marky

    Marky Senior Member (Voting Rights)

    Messages:
    570
    Location:
    Norway
    Should they not spend the time finding out what Fibromyalgia is, instead of treating rats based on hypophezised disease mechanisms?

    Just seems like a waste of time and money to me.
     
  3. shak8

    shak8 Senior Member (Voting Rights)

    Messages:
    1,180
    Location:
    Northen California
    Hutan and alktipping like this.
  4. Jonathan Edwards

    Jonathan Edwards Senior Member (Voting Rights)

    Messages:
    10,287
    Mmm...

    I think I prefer the dead parrot sketch.
     
    shak8, FMMM1, Marky and 3 others like this.

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