Phys.org. Researchers find mitochondria to nucleus messenger protein

If this research is credible, then it sounds like it could be something well worth investigating further regarding ME.

 

Thanks for posting. From my level of ignorance, this looks interesting!

I hope it is something which would be feasible to investigate in ME to see if it is of relevance, or not.

https://phys.org/news/2018-03-mitochondria-to-nucleus-messenger-protein.html

"Mitochondria are special organelles that contain their own DNA. However, the information they store is not sufficient to sustain their own activity or biogenesis. Instead most of the genetic information for mitochondrial proteins is stored in the nuclear DNA. Thus, when the mitochondria are under stress they need to communicate with the nucleus so that it can respond appropriately to help restore their activity or increase in number."

When I had testing done a good many years ago now via Biolab/Myhill on mitos and function I only had 60% of the normal number of mitos.

 

Link to the actual paper, paywalled, is http://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30096-0

 

"The researchers conducted their study in cell cultures and experimental models that had been genetically modified to lose the expression of GPS2."

Just want to point out that the 'experimental models' are mice, which bear little resemblance to humans, especially if they have been genetically modified.

My own studies have shown that such experiments bear little promise for humans.

 

Ah ...

 

I'm not necessarily saying that there is nothing to be said for cell cultures, just that using the wrong species gives the right answer so rarely that it's really not worth doing. It just means a huge amount of suffering. The animals are almost always killed, and large numbers are used in producing the 'right' genotypes.