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Phys.org. Researchers find mitochondria to nucleus messenger protein

Discussion in 'Health News and Research unrelated to ME/CFS' started by NelliePledge, Mar 4, 2018.

  1. NelliePledge

    NelliePledge Senior Member (Voting Rights)

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  2. Barry

    Barry Senior Member (Voting Rights)

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    If this research is credible, then it sounds like it could be something well worth investigating further regarding ME.
     
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  3. Daisymay

    Daisymay Senior Member (Voting Rights)

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    Thanks for posting. From my level of ignorance, this looks interesting!

    I hope it is something which would be feasible to investigate in ME to see if it is of relevance, or not.

    https://phys.org/news/2018-03-mitochondria-to-nucleus-messenger-protein.html

    "Mitochondria are special organelles that contain their own DNA. However, the information they store is not sufficient to sustain their own activity or biogenesis. Instead most of the genetic information for mitochondrial proteins is stored in the nuclear DNA. Thus, when the mitochondria are under stress they need to communicate with the nucleus so that it can respond appropriately to help restore their activity or increase in number."

    When I had testing done a good many years ago now via Biolab/Myhill on mitos and function I only had 60% of the normal number of mitos.
     
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  4. Hutan

    Hutan Moderator Staff Member

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    Interesting @Daisymay. I was just about to ask if there's been any research that has found lower numbers of mitochondria in the cells of people with ME. I vaguely recall there was some research although I can't remember what was found.
     
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  5. Andy

    Andy Committee Member

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    Link to the actual paper, paywalled, is http://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30096-0

     
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  6. MeSci

    MeSci Senior Member (Voting Rights)

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    "The researchers conducted their study in cell cultures and experimental models that had been genetically modified to lose the expression of GPS2."

    Just want to point out that the 'experimental models' are mice, which bear little resemblance to humans, especially if they have been genetically modified.

    My own studies have shown that such experiments bear little promise for humans.
     
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  7. Barry

    Barry Senior Member (Voting Rights)

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    Ah ... :(
     
  8. NelliePledge

    NelliePledge Senior Member (Voting Rights)

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    Thanks @MeSci just shows how easy it is for non scientist like me to get hooked in by a title:whistle:
     
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  9. MeSci

    MeSci Senior Member (Voting Rights)

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    I'm not necessarily saying that there is nothing to be said for cell cultures, just that using the wrong species gives the right answer so rarely that it's really not worth doing. It just means a huge amount of suffering. The animals are almost always killed, and large numbers are used in producing the 'right' genotypes.
     
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