(PhD thesis) In vivo measurement of protein thiol oxidation in skeletal muscle (in CFS), 2020, Boyatzis

[Dolphin]

https://research-repository.uwa.edu.au/en/publications/iin-vivo-imeasurement-of-protein-thiol-oxidation-in-skeletal-musc

In vivo measurement of protein thiol oxidation in skeletal muscle


Amber Boyatzis

• School of Molecular Sciences

Research output: Thesis › Doctoral Thesis

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Abstract

The aim of this work is to establish whether the thiol groups of proteins were a key target of reactive oxygen species as they are contributors to the pathology of many diseases.

Through the development, refinement and application of novel biochemical tools, this work demonstrated that protein thiol oxidation was perturbed in people with Chronic Fatigue Syndrome.

In canine and murine models of Duchenne Muscular Dystrophy, novel proteins undergoing thiol oxidation were identified.

Using the novel tools developed in this work, it will be possible to better understand the mechanism by which reactive oxygen species cause pathology in disease.

Original language English
Qualification Doctor of Philosophy
Awarding Institution

• The University of Western Australia

Thesis sponsors

• Australian Government Research Training Program

Award date 3 Apr 2020
Publication status Unpublished - 2020

• 
  Embargoed Document
• TH20 85 THESIS - DOCTOR OF PHILOSOPHY - BOYATZIS Amber Elizabeth - 2020
  
  9.71 MB

• 
  Embargo ends: 25/07/20
  

 

[alktipping]

I don't understand why a molecular biology study would be awarded a philosophy doctorate .

 

[Trish]

I don't understand why a molecular biology study would be awarded a philosophy doctorate .

It just means a PhD. They are awarded in all subjects.

 

[alktipping]

It just means a PhD. They are awarded in all subjects.

me moment .I thought that after I finishe writing it but it still seems dated to put everthing under philosophy

 

[Jonathan Edwards]

I would say the reverse. It is high time we went back to the concept of 'Natural Philosophy' as the study of the world at all levels, whether physical, biological or metaphysical. The divide between science and philosophy is entirely counterproductive!