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Pharmacogenetics

Discussion in 'Health News and Research unrelated to ME/CFS' started by Amw66, Aug 17, 2018.

  1. Amw66

    Amw66 Senior Member (Voting Rights)

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    Since my daughter experienced side effects from drugs that " have no side effects" ( vit D) , and also glucocorticoids with doctors not really interested in digging deeper, i am interested in how genes and environment may affect responses.

    We have not done 23and me ( mainly because i don't yet know enough to take much forward), but we did a limited DNA test to guide nutrition. This did confirm some hunches, and i am digging deeper into detoxification and methylation ( both with gene combinations, which if expressed would be significant)

    For those struggling with histamine and P450 system issues , both Holland and Australia, have pharmacy guidelines gor those with genetic expression that alters the drug dosage guidelines.
    I am not endorsing self medicating, but there is info which could be very relevant and worth discussing with your doctor/ consultant.

    www.pharmgkb.org/guidelines

    https://cpicpgx.org/guidelines/

    Edit - added second link
     
    Last edited: Aug 17, 2018
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  2. Inara

    Inara Senior Member (Voting Rights)

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    Thanks for those links, @Amw66! I had a WGS analysis and some detoxification genes analyzed, and there were some relevant mutations/deletions. So this may be helpful.
     
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  3. Amw66

    Amw66 Senior Member (Voting Rights)

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    Hopefully your doctor will be interested too ..
     
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