Dolphin
Senior Member (Voting Rights)
I'm not sure whether chronic fatigue syndrome is well-defined or not
https://www.sciencedirect.com/science/article/abs/pii/S1877782121002071
Cancer Epidemiology
Volume 76, February 2022, 102090
Personal history of autoimmune disease and other medical conditions and risk of myelodysplastic syndromes
Amy M.Linabery
Michelle A.Roesler
Michael Richardson
Erica D.Warlick
Phuong L.Nguyen
Adina M.Cioc
Jenny N.Poynter
https://doi.org/10.1016/j.canep.2021.102090
Highlights
•
MDS cases were significantly more likely to have a previous diagnosis of autoimmune disease when compared with controls.
•
Previous diagnosis with autoimmune disease did not impact overall survival following an MDS diagnosis.
•
MDS cases were also more likely to report coronary heart disease and chronic fatigue syndrome than controls.
Abstract
Background
Autoimmune diseases and hematopoietic malignancies are known to cluster within individuals, suggesting intertwined etiologies. A limited number of studies have evaluated pre-existing medical conditions as risk factors for myelodysplastic syndromes (MDS). We evaluated associations between autoimmune disease and other medical conditions and risk of MDS.
Methods
Cases were identified through the Minnesota Cancer Reporting System. Controls were identified through the Minnesota State driver’s license/identification card list. History of autoimmune disease and other medical conditions was based on self-report; proxy interviews were not conducted. Unconditional logistic regression was used to calculate adjusted odds ratios (aORs) and 95% confidence intervals (CI).
Results
We included 395 cases and 694 controls. Cases were significantly more likely to report a diagnosis of any autoimmune disease when compared with controls (aOR=1.41, 95% CI: 1.05–1.89) after adjustment for age, sex, education, NSAID use, exposure to benzene and body mass index. When we evaluated specific autoimmune conditions, a statistically significant association was observed for hypothyroidism (aOR=2.16, 95% CI: 1.39–3.34) and odds ratios were elevated for inflammatory bowel disease (aOR=1.75) and systemic lupus erythematosus (SLE; aOR=3.65), although these associations did not reach statistical significance. Presence of an autoimmune condition did not impact overall survival (p = 0.91).
Conclusion
Our results validate previous findings of an association between autoimmune disease and MDS. Further studies are required to determine whether this association is due to shared etiology, treatment for autoimmune diseases, or altered immune surveillance or bone marrow damage caused by the autoimmune condition.
Keywords
Myelodysplastic syndrome
Autoimmune disease
Chronic immune stimulation
Risk factor
https://www.sciencedirect.com/science/article/abs/pii/S1877782121002071
Cancer Epidemiology
Volume 76, February 2022, 102090
Personal history of autoimmune disease and other medical conditions and risk of myelodysplastic syndromes
Amy M.Linabery
Michelle A.Roesler
Michael Richardson
Erica D.Warlick
Phuong L.Nguyen
Adina M.Cioc
Jenny N.Poynter
https://doi.org/10.1016/j.canep.2021.102090
Highlights
•
MDS cases were significantly more likely to have a previous diagnosis of autoimmune disease when compared with controls.
•
Previous diagnosis with autoimmune disease did not impact overall survival following an MDS diagnosis.
•
MDS cases were also more likely to report coronary heart disease and chronic fatigue syndrome than controls.
Abstract
Background
Autoimmune diseases and hematopoietic malignancies are known to cluster within individuals, suggesting intertwined etiologies. A limited number of studies have evaluated pre-existing medical conditions as risk factors for myelodysplastic syndromes (MDS). We evaluated associations between autoimmune disease and other medical conditions and risk of MDS.
Methods
Cases were identified through the Minnesota Cancer Reporting System. Controls were identified through the Minnesota State driver’s license/identification card list. History of autoimmune disease and other medical conditions was based on self-report; proxy interviews were not conducted. Unconditional logistic regression was used to calculate adjusted odds ratios (aORs) and 95% confidence intervals (CI).
Results
We included 395 cases and 694 controls. Cases were significantly more likely to report a diagnosis of any autoimmune disease when compared with controls (aOR=1.41, 95% CI: 1.05–1.89) after adjustment for age, sex, education, NSAID use, exposure to benzene and body mass index. When we evaluated specific autoimmune conditions, a statistically significant association was observed for hypothyroidism (aOR=2.16, 95% CI: 1.39–3.34) and odds ratios were elevated for inflammatory bowel disease (aOR=1.75) and systemic lupus erythematosus (SLE; aOR=3.65), although these associations did not reach statistical significance. Presence of an autoimmune condition did not impact overall survival (p = 0.91).
Conclusion
Our results validate previous findings of an association between autoimmune disease and MDS. Further studies are required to determine whether this association is due to shared etiology, treatment for autoimmune diseases, or altered immune surveillance or bone marrow damage caused by the autoimmune condition.
Keywords
Myelodysplastic syndrome
Autoimmune disease
Chronic immune stimulation
Risk factor
