Yes, so there are four related papers.
Step on the 129Xe Gas: The MRI Race to Uncover Drivers of Post-COVID-19 Symptoms, 2022
Grace Parraga
and
Alexander M. Matheson
Editorial in the Radiology journal commenting on the Grist, Collier, Wild paper
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134267/
Persistent 129Xe MRI Pulmonary and CT Vascular Abnormalities in Symptomatic Individuals with Post-Acute COVID-19 Syndrome
Alexander M. Matheson BSc1,2, Marrissa J. McIntosh BSc1,2, Harkiran K. Kooner BSc1,2, Justin Lee3, Vedanth Desaigoudar1,2, Elianna Bier MS4, Bastiaan Driehuys PhD4, Sarah Svenningsen PhD5, Giles E. Santyr PhD6,7, Miranda Kirby PhD8, Mitchell S. Albert PhD9-11, Yurii Shepelytskyi PhD9,10, Vira Grynko MSc9,10, Alexei Ouriadov PhD12, Mohamed Abdelrazek MD PhD13, Inderdeep Dhaliwal MD14, J. Michael Nicholson MD14 and
Grace Parraga PhD
see Trish's post above for the abstract
Lung Abnormalities Depicted with Hyperpolarized Xenon MRI in Patients with Long COVID, 2022
James T. Grist, BSc PhD,1,,2,,3,,4
Guilhem J. Collier, PhD,5
Huw Walters, MBBS,1
Minsuok Kim, PhD,6
Mitchell Chen, BMBCh MEng DPhil FRCR,1
Gabriele Abu Eid, BSc,1
Aviana Laws,1
Violet Matthews, BSc,1
Kenneth Jacob, BSc,1
Susan Cross, BSc,1
Alexandra Eves, BSc,1
Marianne Durant, BSc,1
Anthony Mcintyre, BAppSci,1
Roger Thompson, PhD,7
Rolf F. Schulte, PhD,8
Betty Raman, MBBS DPhil,3
Peter A. Robbins, PhD,2
Jim M. Wild, PhD MSc MA,5
Emily Fraser, PhD MBChB BSc,9 and
Fergus Gleeson, MBBS
1,,10
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134268/
Abstract
Background
Post-Covid-19 condition describes symptoms following COVID-19 infection after four weeks. Symptoms are wide-ranging but breathlessness is common.
Purpose
The purpose of this study was to determine whether the previously described lung abnormalities on Hp-XeMRI in post-hospitalised COVID-19 participants are also present in non-hospitalised participants with Post-Covid-19 condition.
Methods
In this prospective study, non-hospitalised Post-Covid-19 condition (NHLC) and post-hospitalised COVID-19 (PHC) participants were enrolled from 06/2020 to 08/2021. Participants had chest CT, hyperpolarized pulmonary 129Xenon MRI (Hp-XeMRI), pulmonary function tests, 1-minute sit-to-stand test and breathlessness questionnaires. Control subjects underwent HP-XeMRI only. CT scans were analysed for post COVID interstitial lung disease severity using a previously published scoring system, and Full-scale Airway Network (FAN) modelling. Analysis used group and pair-wise comparisons between participants and controls, and correlations between participant clinical and imaging data.
Results
A total of 11 NHLC (4:7 Male: Female, 44 ± 11 years, [37-50], (mean ± SD, [95% CI]) and 12 PHC (10:2, Male: Female, 58 ± 10 years, [52-64]) participants were included, with a significant difference in age between groups, p = 0.05. NHLC participants were 287 ± 79, [240-334] and PHC 143 ± 72, [105-190] days from infection, respectively. NHLC and PHC participants had normal or near normal CT scans (0.3/25 ± 0.6, [0-0.63] and 7/25 ± 5, [4-10], respectively). Gas transfer (DLco (%)) was different between NHLC and PHC participants (76 ± 8%, [73-83] vs 86 ± 8%, [80-91] respectively, p = 0.04) but there was no evidence of other differences in lung function. Red Blood Cell:Tissue Plasma (RBC:TP) mean was different between volunteers vs PHC (0.45 ± 0.07, [0.43-0.47] vs (0.31 ± 0.10, [0.24-0.37], respectively, p = 0.02) and volunteers vs NHLC (0.37 ± 0.10, [0.31-0.44], p = 0.03) participants, but not between NHLC and PHC participants (p = 0.26). FAN results did not correlate with DLco or Hp- XeMRI.
Conclusion
NHLC and PHC subjects showed Hp-XeMRI RBC:TP abnormalities, with NHLC participants demonstrating lower DLco than PHC participants despite having normal CT scans.
129 Xe Pulmonary MRI for Individuals with Post-Acute COVID-19 Syndrome
Jim M Wild 1,
Guilhem Collier 1
Online ahead of print
here
Editorial commenting on the Matheson paper