Patent in Artificial Intelligence - Healthcare

mariovitali

mariovitali

Senior Member (Voting Rights)
Dear All,


I am very happy to say that i successfully filed for a US patent for a methodology that uses Artificial Intelligence, Network Analysis and Text Analysis algorithms to generate hypotheses for any disease, group of symptoms or syndromes.

The patent application can be found here in case anyone is interested :

https://patentscope.wipo.int/search...ter=&sortOption=Pub+Date+Desc&maxRec=71584081

The methodology is currently used for ME Research in order to identify highly promising targets. Every time that there are any findings that are able to differentiate ME patients vs Controls, they are added to the system and the system re-evaluates and identifies targets that are more likely to be key factors that are responsible for ME.

As a quick summary, The AI approach suggests that (as hypotheses) :

-The common factor that starts ME is Liver Injury that originates from viruses, toxic substances or medications (possibly through disruption of mitochondrial function)

-There are no individual genes responsible for ME but a combination of genes to certain critical pathways. It is this combination that creates a vicious cycle that needs to be halted. This means that it is unlikely that there will be a "one-fits-all" treatment and a personalised treatment is more likely to have the best outcome.

A quick update related to the use of this methodology and ME :


-The latest results (=research targets) will be presented to the CureME team of the London School of Hygiene and Tropical Medicine (LSHTM) via a Zoom meeting on July 23rd (not publicly streamed) in hope that they may be of use to the team's future research activities.

-Practical suggestions will be given for future patient Questionnaire entries, hypotheses on why certain supplements may be harmful/beneficial to ME patients, etc.

-Certain hypotheses will be presented on compounds that may be beneficial for ME symptom amelioration.

These hypotheses will be also communicated to a selected number of American ME researchers.


I would like to Thank all of you for your support, suggestions and comments throughout these past years.
 
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Maybe the liver comes up not because it's the center of the illness, but the center of metabolism in the body. If you selected a random metabolite or pathway in the body, chances are high it would be closely connected to the liver (I don't know if this is accurate but it illustrates the idea).

Does this tool rate the liver as important in similar diseases we understand better and where the liver is not considered important?
 
strategist said:
Maybe the liver comes up not because it's the center of the illness, but the center of metabolism in the body. If you selected a random metabolite or pathway in the body, chances are high it would be closely connected to the liver (I don't know if this is accurate but it illustrates the idea).

Does this tool rate the liver as important in similar diseases we understand better and where the liver is not considered important?
Click to expand...

Good comment there, Thank you @strategist

The system outputs important components on any given disease. This has nothing to do with causes however. I tried to incorporate biological pathways relationships to perform root cause hypotheses although this work is not part of the patent.

So yes, the liver is there because it is considered a core component of the pathology. Nevertheless, if this is indeed true then that would mean that we must focus on more general research targets such as the mitochondria and other metabolic pathways rather than the immune system and viruses.

Focusing on the most probable targets brings down costs but also -more importantly- it helps us find a cure more quickly, instead of having humans making the hypotheses.

I hope I answered your questions !

(Edited for clarity)
 
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I ended up at the liver potentially being my central cause as well,specifically under active enzyme of the urea cycle possibly resulting in (minimal?)ammonia passing through to detox in the brain and or muscle
 
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wastwater said:
It seems I ended up at the liver being my central cause as well,specifically under active enzyme of the urea cycle resulting in minimal ammonia passing through to detox in the brain and or muscle
Click to expand...

I am glad that you managed to find what was responsible in your case.

Which enzyme are you referring at? Have you started treating your condition ?
 
Genetically I have a distant connection to NAGS deficiency I’m hoping it maybe partial NAGS with treatment but it maybe a long shot
It’s treatment is carglumic acid and it’s expensive

I hadn’t heard of Late onset urea cycle disorders until recently
They can be connected to rare genetic disorders but you may not know if you have a rare genetic disorder as well
 
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wastwater said:
Genetically I have a distant connection to NAGS deficiency I’m hoping it maybe partial NAGS with treatment but it maybe a long shot
It’s treatment is carglumic acid and it’s expensive

I hadn’t heard of Late onset urea cycle disorders until recently
They can be connected to rare genetic disorders but you may not know if you have a rare genetic disorder as well
Click to expand...

So i assume you have found elevated ammonia levels. Are you looking / have you already looked at getting a proper evaluation by a specialist in Urea disorders to confirm the diagnosis?
 
I worked out that theoretically my NAGS gene will be underactive along with a gene for pyruvate
Maybe low pyruvate makes it harder to detox ammonia
 
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