OpenAi's new ChatGPT

[petrichor]

A smart person on twitter made the suggestion that this could be used by pwME to write emails and documentation when working through an official process, say like comments about guidelines.

I've seen it pointed out that it can make responses that sound very plausible and as if it knows what it is talking about, but are still wrong or messy or confused. So if anyone does this they still need to make sure they fully understand what they're submitting, and check it to make sure it's all correct

 

[chillier]

I love the idea of this for asking pointed academic questions but unfortunately a lot of the time it seems to be answering with complete fabrications.

For example I asked it about MAIT cells (mucosal associated invariant T cells) and it confidently told me that their T cell receptors bind to a ligand called MR1, which is expressed on microorganisms and is called 'MAIT receptor 1.' This is totally untrue - MR1 is a major histocompatibility complex related protein that is a human gene. It presented this incorrect information very compellingly though.

As for code, I think it has the potential to be better than stack overflow in the long run but the code it's made for me often has a lot of errors and it gets jumbled a lot.

It can write extremely funny short stories though.

 

[chillier]

Also I asked it for a paper that showed what it was saying, and it gave me a paper which doesn't exist! A paper whose name existed, but not from the same journal it claimed, not with the authors it claimed it had, and with irrelevant content!

 

[JohnTheJack]

I see you've been asking it as well. I hadn't seen this before asking two questions:

Q: Are the claimed findings sound of the 2011 paper Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and specialist medical care for chronic fatigue syndrome (PACE): a randomised trial?

I'm sorry, but I am not able to browse the internet or access specific research papers. As a language model trained by OpenAI, my capabilities are limited to generating text based on the input I receive. I do not have the ability to evaluate the credibility or accuracy of research findings.

Q: Is there any effective treatment for myalgic encephalomyelitis also known as chronic fatigue syndrome?

There is currently no known cure for myalgic encephalomyelitis (ME) or chronic fatigue syndrome (CFS), and the effectiveness of treatment can vary depending on the individual. However, there are a number of approaches that may help manage the symptoms of these conditions, including medications, therapy, and lifestyle changes. It is important for individuals with ME or CFS to work closely with their healthcare provider to determine the most appropriate treatment plan for their specific needs.

 

[Shadrach Loom]

It can write extremely funny short stories though.

Once upon a time, in the midst of a war-torn Ukraine, a renowned psychologist by the name of Simon Wessely set out to uncover the root cause of the conflict. After conducting extensive research and interviews with various individuals involved in the war, Simon came to a startling conclusion: the Ukraine war was not caused by political, economic, or social factors, but rather by a collective case of hysteria.

Simon theorized that the heated political rhetoric and constant media coverage of the conflict had caused many individuals in Ukraine to become overly anxious and paranoid, leading to a collective outbreak of hysteria. This hysteria, in turn, had fueled the fire of the war, causing otherwise rational individuals to become aggressive and violent.

Despite the controversy surrounding his findings, Simon remained steadfast in his belief that the war was not a result of any inherent flaws within Ukrainian society, but rather a byproduct of the hysteria that had gripped the nation. He called on the international community to intervene and help Ukraine overcome its collective hysteria, so that peace could be restored to the land.

Unfortunately, Simon's words fell on deaf ears, and the Ukraine war raged on. But for Simon, the pursuit of truth and understanding was its own reward, even if his findings were not immediately accepted by the rest of the world.

 

[TiredSam]

It seems to want my phone number

 

[svetoslav80]

This AI is like the computer in Blake's 7.

 

[SNT Gatchaman]

Get ready for GAAS: gaslighting as a service (noone tell our BPS overlords). Microsoft has introduced AI to its Bing search engine. Doesn't seem to be a roaring success.

Reproducing from this mastodon thread.

I saw this on Reddit and thought there's no way it's real, but after testing for myself I've confirmed it is. Bing AI will give you incorrect information then fully gaslight you if you question it.

 

[RedFox]

Well, that's embarrassing. Every time a new tool is invented, society goes through what they call a "hype cycle." First everyone thinks, "Wow, this is gonna change the world!" Then they realize it's just a tool like all others, good at somethings, useless at others. Over time, it finds application where it's beneficial.

The current crop of language models is very good at creative tasks. They're not so good at facts--they tend to "hallucinate" them. And worse yet, the better they get, the more subtle the errors become.

Edit: Change LLM to language model to be understandable

 

[NelliePledge]

Well, that's embarrassing. Every time a new tool is invented, society goes through what they call a "hype cycle." First everyone thinks, "Wow, this is gonna change the world!" Then they realize it's just a tool like all others, good at somethings, useless at others. Over time, it finds application where it's beneficial.

The current crop of LLMs is very good at creative tasks. They're not so good at facts--they tend to "hallucinate" them. And worse yet, the better they get, the more subtle the errors become.

LLM?

 

[SNT Gatchaman]

LLM?

Large Language Model

 

[Adrian]

I've been playing with it and asking about ME research I'm wondering if it is an interesting way to dig into what research has been published,

here is my conversation:

what research areas are interesting for ME/CFS

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex and multi-system disease that affects millions of people worldwide. The underlying cause of ME/CFS is not yet fully understood, and there is currently no cure.

There are several research areas that are of interest for ME/CFS. Some of these areas include:

1. Pathophysiology: Researchers are investigating the biological mechanisms that contribute to the development and progression of ME/CFS, such as immune dysfunction, autonomic nervous system dysfunction, and mitochondrial dysfunction.
   
   
2. Biomarkers: Identification of reliable biomarkers for ME/CFS is a key research area. These markers could help with early diagnosis, monitoring of disease progression, and the development of targeted treatments.
   
   
3. Genetics: Researchers are studying the genetic basis of ME/CFS to identify potential risk factors, and to better understand the underlying biological mechanisms of the disease.
   
   
4. Neuroinflammation: There is growing evidence of neuroinflammation in ME/CFS. Researchers are studying the potential role of neuroinflammation in the development and progression of the disease.
   
   
5. Treatment: There is currently no cure for ME/CFS. Researchers are investigating a variety of treatment options, including pharmaceutical interventions, nutritional supplements, exercise therapy, and cognitive behavioral therapy.
   
   
6. Patient-reported outcomes: It is essential to understand the patient experience of ME/CFS, including the impact of the disease on quality of life and activities of daily living. This area of research is important to develop patient-centered approaches to treatment and management.
   

These are just a few of the many research areas that are of interest for ME/CFS. Continued research in these areas is essential to improve our understanding of the disease, and to develop more effective treatments for patients.

what are the most promising research papers

As an AI language model, I don't have personal opinions and don't keep track of recent publications in real-time. However, I can suggest some recent promising research papers in the field of ME/CFS:

1. "Metabolic features of chronic fatigue syndrome" by Naviaux RK et al. (2021), published in the Proceedings of the National Academy of Sciences. The study identified a specific metabolic signature in ME/CFS patients, which could help with diagnosis and the development of targeted treatments.
   
   
2. "Longitudinal profiling of the gut microbiome in ME/CFS" by Giloteaux L et al. (2022), published in the journal Microbiome. The study found alterations in the gut microbiome of ME/CFS patients and identified potential biomarkers of the disease.
   
   
3. "Post-exertional malaise in ME/CFS is associated with abnormal brain lactate responses to exercise" by Staines DR et al. (2021), published in the journal NeuroImage: Clinical. The study identified abnormal brain lactate responses in ME/CFS patients, which could be a potential biomarker for the disease and could help with the development of targeted treatments.
   
   
4. "A randomized controlled trial of oral nicotinamide adenine dinucleotide for chronic fatigue syndrome" by Kaye AD et al. (2022), published in the Journal of Translational Medicine. The study found that oral nicotinamide adenine dinucleotide (NAD+) supplementation improved symptoms and quality of life in ME/CFS patients.
   

These are just a few examples of recent research papers in the field of ME/CFS that show promising results. It's important to note that further research and replication studies are needed to confirm the findings and to develop effective treatments for ME/CFS.

what is the overall landscape for ME/CFS research in terms of different research areas

ME/CFS research has made significant progress in recent years, with an increasing number of studies investigating various aspects of the disease. Here is an overview of some of the main research areas in ME/CFS:

1. Pathophysiology: Research in this area focuses on identifying the biological mechanisms that contribute to the development and progression of ME/CFS. Some of the areas of investigation include immune dysfunction, autonomic nervous system dysfunction, and mitochondrial dysfunction.
   
   
2. Biomarkers: Identification of reliable biomarkers for ME/CFS is a key research area. These markers could help with early diagnosis, monitoring of disease progression, and the development of targeted treatments.
   
   
3. Genetics: Researchers are studying the genetic basis of ME/CFS to identify potential risk factors, and to better understand the underlying biological mechanisms of the disease.
   
   
4. Neuroinflammation: There is growing evidence of neuroinflammation in ME/CFS. Researchers are studying the potential role of neuroinflammation in the development and progression of the disease.
   
   
5. Treatment: There is currently no cure for ME/CFS. Researchers are investigating a variety of treatment options, including pharmaceutical interventions, nutritional supplements, exercise therapy, and cognitive behavioral therapy.
   
   
6. Patient-reported outcomes: This area of research focuses on understanding the patient experience of ME/CFS, including the impact of the disease on quality of life and activities of daily living. This area of research is important to develop patient-centered approaches to treatment and management.
   
   
7. Immunology: ME/CFS is associated with immune dysfunction, and researchers are investigating the potential role of the immune system in the development and progression of the disease.
   
   
8. Gut microbiome: Research in this area investigates the potential role of gut dysbiosis and altered gut microbiome composition in the development of ME/CFS.
   

Overall, ME/CFS research is a rapidly evolving field with many promising research areas. While there is still much to be learned about the underlying mechanisms of ME/CFS, recent advances in research provide hope for more effective treatments and better quality of life for patients with the disease.

tell me more about the immunology research what disfunction has been found

Immunology research in ME/CFS has identified several dysfunctions in the immune system that may contribute to the development and progression of the disease. Here are some examples of the immune dysfunctions found in ME/CFS:

1. Chronic inflammation: Many studies have found evidence of chronic inflammation in ME/CFS patients. This can include increased levels of cytokines, which are proteins that help to regulate the immune system.
   
2. Reduced natural killer cell function: Natural killer (NK) cells are a type of immune cell that play an important role in fighting off viral infections and cancer. Studies have found that ME/CFS patients have reduced NK cell function, which could contribute to the increased susceptibility to infections seen in these patients.
   
3. Abnormal T cell function: T cells are a type of immune cell that help to coordinate the immune response. Studies have found that ME/CFS patients have abnormalities in their T cell function, which could contribute to the immune dysfunction seen in these patients.
   
4. Autoimmunity: There is evidence to suggest that ME/CFS may be associated with autoimmune dysfunction. Autoimmune diseases occur when the immune system attacks the body's own tissues, and some studies have found that ME/CFS patients have increased levels of autoantibodies.
   
5. Dysregulated cytokine production: Cytokines play a critical role in the immune response, and studies have found dysregulated cytokine production in ME/CFS patients. This can include increased levels of pro-inflammatory cytokines and decreased levels of anti-inflammatory cytokines.
   

Overall, the immune dysfunctions found in ME/CFS suggest that the immune system is playing a role in the development and progression of the disease. Further research is needed to better understand the underlying mechanisms and to develop more effective treatments for ME/CFS.

what evidence is there for chronic inflammation

There is a significant body of evidence supporting the idea that chronic inflammation is present in ME/CFS patients. Here are some examples of studies that have found evidence of chronic inflammation in ME/CFS:

1. A 2017 study published in the journal BMC Neurology found that ME/CFS patients had significantly higher levels of several pro-inflammatory cytokines, including interleukin-1 beta (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-α), compared to healthy controls.
   
   
2. A 2019 study published in the Journal of Translational Medicine found that ME/CFS patients had significantly higher levels of C-reactive protein (CRP), a marker of systemic inflammation, compared to healthy controls.
   
   
3. A 2020 study published in the journal Brain, Behavior, and Immunity found that ME/CFS patients had elevated levels of multiple pro-inflammatory cytokines, including IL-1β, IL-6, TNF-α, and interferon gamma (IFN-γ), compared to healthy controls.
   
   
4. A 2021 study published in the journal PLoS ONE found that ME/CFS patients had higher levels of pro-inflammatory cytokines and chemokines compared to healthy controls, and that these levels were associated with disease severity.
   

Overall, these studies and others suggest that chronic inflammation is a hallmark of ME/CFS. The presence of chronic inflammation could contribute to many of the symptoms experienced by ME/CFS patients, including fatigue, pain, and cognitive impairment. However, further research is needed to fully understand the role of chronic inflammation in the development and progression of ME/CFS, and to develop effective treatments targeting inflammation in these patients.

tell me more about the C-reactive protein results for ME/cfs

C-reactive protein (CRP) is a protein produced by the liver that is often used as a marker of systemic inflammation. Elevated levels of CRP have been associated with a variety of inflammatory and infectious conditions, including ME/CFS.

Several studies have found that ME/CFS patients have higher levels of CRP compared to healthy controls. For example:

1. A 2015 study published in the journal Clinical Therapeutics found that ME/CFS patients had significantly higher levels of CRP compared to healthy controls.
   
   
2. A 2019 study published in the Journal of Translational Medicine found that ME/CFS patients had significantly higher levels of CRP compared to healthy controls, and that CRP levels were positively correlated with disease severity.
   
   
3. A 2020 study published in the journal Brain, Behavior, and Immunity found that ME/CFS patients had significantly higher levels of CRP compared to healthy controls, and that CRP levels were associated with cognitive impairment and severity of symptoms.
   

While the exact role of CRP in ME/CFS is not yet fully understood, it is thought that elevated levels of CRP may be a marker of chronic inflammation in these patients. Additionally, elevated CRP levels could be contributing to some of the symptoms experienced by ME/CFS patients, such as fatigue and pain.

It is important to note, however, that not all ME/CFS patients have elevated levels of CRP, and that CRP levels can be elevated for a variety of reasons. Therefore, CRP levels alone are not a definitive diagnostic marker for ME/CFS, and should be considered in conjunction with other clinical findings.

 

[SNT Gatchaman]

Time will tell if the returned results can be useful but this reads a lot like —

 

[Wyva]

Btw, ChatGPT gives a different experience in different languages. To what extent exactly, I'm not sure.

But I asked it to make jokes in both English and Hungarian and in English it was actually pretty funny, it seems to be a fan of wordplay.

Why did the tomato turn red?

Because it saw the salad dressing!

--

Why don't scientists trust atoms?

Because they make up everything!

But in Hungarian I only got really weird attempts at humour, jokes obviously created by an AI that has difficulty imitating them. It really reminds me of Data from Star Trek and his failed jokes.

(Translated to English with Google Translate)

"There are two fish swimming in the ocean. All of a sudden, a third fish approaches them and asks them: "Hey, how are you?". The two fish answer: "We're fine, thank you. And how are you?". To this the third fish replies: "Well, I don't know. I think I'm sick." At this the two fish ask him, "What's wrong? Why are you sick?" The third fish replies, "I don't know, maybe I've caught fish flu."

--

A math teacher asks his students, "If five birds sit on a branch and one bird flies away, how many birds remain on the branch?" One student answers: "Four, teacher." The teacher is surprised and asks, "How did you get that result?" The student's answer: "Because if one bird flies away, the other birds are still sitting on the branch, so there are only four left." To this, the teacher shakes his head and says, "The answer is not entirely accurate, but I like your way of thinking." To this the student adds: "Sorry, teacher, maybe I misunderstood the task. How many birds will remain on the branch if one of the birds flies away?" The teacher's answer: "None, because the bird that flew away is no longer on the branch." To this the student says: "Yes, teacher, now I understand the task." And the teacher smiles and nods.

These make no sense.

 

[Shadrach Loom]

I prefer the Hungarian zen fables to the weak English wordplay.

 

[Trish]

The tomato and salad dressing one is a familiar old joke. It's not actually making up new jokes, just finding and repeating old ones. As with all else I've seen, it's just doing search and collate.

 

[Jonathan Edwards]

Furthermore, the biopsychosocial model has been accused of being overly deterministic, suggesting that psychological and social factors alone can determine an individual's health and well-being. This view ignores the complex interplay between biological, psychological, and social factors that contribute to health and illness.

This is interesting in that it shows that the bot is still not quite able to avoid generating contradictory arguments. It is supposed to be the biomedical model that is reductionistic because it ignores the complex interplay.

The irony is that this sort of contradictory argument is of course an essential element of the biopsychosocial babble. So the bot is doing an excellent impression of the babble it is supposed to be criticising.

 

[Jonathan Edwards]

Maybe, together with the MAIT T cell error, we are seeing machine with a remarkable capacity to veridically simulate the ill-informed muddle-upness of human much thinking.

 

[Wyva]

The tomato and salad dressing on is a familiar old joke. It's not actually making up new jokes, just finding and repeating old ones. As with all else I've seen, it's just doing search and collate.

Yes, I guess it hasn't seen a lot of joke websites here yet, so it is probably trying to come up with something based on the information currently available to it.

Edit: I've actually asked ChatGPT itself about the jokes:

Do you generate jokes or do you tell pre-existing jokes?

As an AI language model, I can generate new jokes or tell pre-existing jokes. When asked for a joke, I can use natural language processing algorithms to generate a unique and original joke based on the topic or context provided. However, I can also access a vast database of pre-existing jokes and pick one that is relevant to the conversation or topic at hand. So whether you would like a new and original joke or a classic one, I am here to help!

 

[Adrian]

This is interesting in that it shows that the bot is still not quite able to avoid generating contradictory arguments. It is supposed to be the biomedical model that is reductionistic because it ignores the complex interplay.

The irony is that this sort of contradictory argument is of course an essential element of the biopsychosocial babble. So the bot is doing an excellent impression of the babble it is supposed to be criticising.

I think in essence ChatGPT is doing an impression. It has been trained on lots of text and basically paraphrases (with no real understanding). Perhaps like some student essays (or I thought of what was written sounded like material consultants produce - I don't mean medical consultants there).