Ontario researchers make major ALS breakthrough in the race to find a cure. Here’s what they found

The researchers believe their treatment can reach clinical trials in just five years. We break down how it works.

Strong and his team’s most recent breakthrough came after discovering that a tiny, specific fragment of RGNEF was able to mitigate the toxic effects of TDP-43. This fragment contained a small loop that appeared to interact directly with a “critical pocket” of TDP-43 and, in doing so, reduce its toxicity, he explained.

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