Ontario researchers make major ALS breakthrough in the race to find a cure. Here’s what they found

Discussion in 'Other health news and research' started by Mij, May 21, 2024.

  1. Mij

    Mij Senior Member (Voting Rights)

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    The researchers believe their treatment can reach clinical trials in just five years. We break down how it works.

    Strong and his team’s most recent breakthrough came after discovering that a tiny, specific fragment of RGNEF was able to mitigate the toxic effects of TDP-43. This fragment contained a small loop that appeared to interact directly with a “critical pocket” of TDP-43 and, in doing so, reduce its toxicity, he explained.

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