OK brain trust! My own thread about how pwME ignore symptoms that may be something else has shamed me. Apologizing in advance for the long description of the symptom/history, but it's complex. Using boldface to try and make it easier to read! About a year ago working at Stanford, my left leg began to go out from under me entirely. This used to be a symptom of pure exhaustion, when I'd overdone it... but it was usually a sign of SEVERE crash at that time. I was far, far more likely to simply have trouble moving in the first place. At Stanford I did lab work, sometimes for hours at a time without rest, and I think that there is a certain focus in staying upright under those conditions. Once I let that focus relax, my left side would just sort of... give out. And even though I'm upright less often now, working from home about 75% of the time, and when I am upright, it's for a shorter period of time. And it's still happening. If anything, it's getting a wee bit worse. No serious falls. Once or twice I've been in the middle of a hallway without anything to grab and gone down rather sharply on my hands and/or knees, that's about it. It's not like my leg is 'turning off' like a light switch; I can usually catch myself which, I think, means that it's a sudden weakness not a sudden paralysis. It can worsen in correlation with other symptoms but honestly it can happen even if I'm doing pretty darned well, otherwise. Did actually brave a convo with the doctor where I raised a concern that it might be dopamine-related. I know I have a dopamine receptor mutation that incurs some loss of function in DRD2, and both my mom and sister (who also have ME) have documented dopamine-related issues (restless leg, e.g.). I was told it was "probably a pinched nerve" with a wave of one hand. Not only are there dozens of potential reasons for one-sided weakness, but even on medical websites "chronic fatigue" is listed as one of them. Could it be that I've simply exhausted my resources and the largest weak muscle(s) is/are giving out? Open to speculation about what's causing this or what might be useful for further testing.