OMF: Muscle Biopsy and Plasma Study into Post-Exertional Malaise, David Systrom, 2022

[wigglethemouse]

I asked Google AI "". This was the No. 1 answer which seems to tie in with the Beentjes paper findings.

Capillary basement membrane thickening in muscle tissue is most commonly associated with diabetes mellitus, specifically diabetic microangiopathy. However, it can also occur in other conditions, including collagen diseases, atherosclerotic vascular disease, and even congestive heart failure.
Here's a more detailed breakdown:

1. Diabetes Mellitus:
* Thickening of the capillary basement membrane is a hallmark of diabetic microangiopathy, a complication of diabetes.
* This thickening is particularly noticeable in the capillaries of skeletal muscle.
* The thickening is linked to changes in blood glucose levels and other metabolic abnormalities associated with diabetes.
* It's not solely determined by blood glucose levels, as some individuals with hyperglycemia from other causes don't exhibit the same degree of thickening.
* Genetic factors and insulin deficiency also play a role

If this occurs in the skin as well it could be the reason for peripheral neuropathy similar to diabetic neuropathy? I hope the Dr Systrom study looks for capillary basement thickening in muscle to see if it correlates to small fiber neuropathy biopsy findings.

Does this ring any bells with anyone?

 

[Hutan]

Post-COVID exercise intolerance is associated with capillary alterations and immune dysregulations in skeletal muscles, 2023 Aschman et al
has some data on capillary basement thickness from a small study of post-Covid syndrome with PEM. It seems to indicate a significant consistent thickening - but yes, a small study, especially with the number and nature of the controls.