October 2025 IACFS/ME Conference

www.iacfsme.org

2025 Medical and Scientific Conference - Learn More!

International Association for Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis (IACFS/ME) 17th Research and Clinical Conference Virtual Conference October 22 – 25, 2025 REGISTER NOW! …
www.iacfsme.org www.iacfsme.org

Register by September 7, 2025 at 11:59 PM to receive a $50 early bird discount!

Registration Ends: October 20, 2025 at 9 AM, New York City Time.
Click Here to Register for the Conference!
Click here for registration fees and policies.
For Conference Schedule, Click Here!
 
Attend the 2025 IACFS/ME Conference for free!


Enter a drawing for one (1) of five (5) Patient/ Public tickets

to the conference from now through October 12, 2025, 11:59 PM (New York City time)!

This drawing is sponsored by the Dabdoub Law Firm.



Click here to enter your name/ e-mail address!

No purchase or payment is needed to enter the drawing.

Only one entry per person please.​



WHO: Legal residents of their respective countries where drawings are not prohibited by law, who are eighteen (18) years of age or older at the time of entry.



WHAT: Five (5) Patient/Public conference attendance tickets will be awarded to five (5) winners with each winner receiving one ticket. Each ticket is worth $250 USD. Patient/ Public tickets allow entry to all the same talks, workshops, and sessions as Professional-level tickets EXCEPT continuing medical education (CME) credits are not awarded.



The IACFS/ME 2025 Conference takes place online from October 22-25, 2025, from 9 AM to 4 PM New York City time. Please see the main conference webpage for details. A schedule of the conference can be viewed here.



WHERE/ WHEN: Each entry will be assigned a number. Five winners will be selected using an online random number generator on October 13, 2025. Winners will be announced immediately after the drawing. Notification of and instructions to receive/ use the prize will be sent to the e-mail address supplied by the entrant on the online entry form. Each entrant is responsible for monitoring his/her e-mail inboxes for prize notification and other communications related to this drawing. Tickets may be rescinded if not claimed within five days (5) after the drawing (October 17, 2025).



HOW: Enter by submitting your name and e-mail address on this form. By participating, each entrant consents to receive informational and promotional information via e-mail from the organizers, IACFS/ME and the Dabdoub Law Firm. Entrants can unsubscribe from e-mails at any time and can also contact organizers to stop. Names and e-mail addresses will not be shared with entities outside of the organizers.



For more details about the drawing, see this document. For questions, contact IACFS/ME at iacfsmeorg@gmail.com.





Mark your calendars!



Everyone is also welcomed to attend the Dabdoub Law Firm’s presentation at the IACFS/ME Conference on October 23, from 3:35 to 4:35 PM. Edward Dabdoub will present on “How to Effectively Handle ME/CFS Disability Insurance Claims”. Bring your questions about disability insurance claims to this meeting! No ticket is required to attend nor do you need to participate in the ticket drawing. A link to the presentation will be sent later and will also be included on the main conference webpage starting October 13.



This email was sent on behalf of International Association for Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis (IACFS/ME) located at ATTN: Dr. Fred Friedberg, IACFS/ME, P.O. Box 583, Stony Brook, NY 11790.

Click to expand...
 
Role Reversal: Could a WEAKENED Fight/Flight Response Be Causing ME/CFS and Long COVID? The 2025 IACFS/ME Conference Pt. I

by Cort Johnson
| Nov 11, 2025 |

Astrocytes, Autonomic Nervous System, Brain, Brainstem, Dopamine, Energy Production, Homepage, Locus coeruleus, long COVID, Neuroinflammation, Neuroinflammation, Norepinephrine, Oxidative Stress, Research, Sleep |

https://www.healthrising.org/blog/2025/11/11/fight-flight-system-chronic-fatigue-long-covid/
 
Last edited:
Dolphin said:
Role Reversal: Could a WEAKENED Fight/Flight Response Be Causing ME/CFS and Long COVID? The 2025 IACFS/ME Conference Pt. I
Click to expand...
Fascinating article. It seems like a follow-up to the Walitt paper that found catechol anomaly. I always ask how the hypothesis explains PEM, and this one seems to attribute it to norepinephrine depletion in LC vesicle. Not sure how that would work for PEM lasting weeks or months. I'll looking forward to reading the actual paper when it is published.

edit: dopamine -> norepinephrine
 
Last edited:
I find Cort's articles impossible to guage, as he has a tendency to report some research findings probably fairly accurately, then extrapolate wildly in an apparent effort to connect a single research finding to loads of unevidenced and fringe claims and treatments.

Until the research is published or a video of the talk made available, we have no way of knowing what in this article is direct from the research and what is only in Cort's imagination. I think that is very unhelpful.
 
Trish said:
I find Cort's articles impossible to guage, as he has a tendency to report some research findings probably fairly accurately, then extrapolate wildly in an apparent effort to connect a single research finding to loads of unevidenced and fringe claims and treatments.
Click to expand...
I agree that this is very frustrating and, even if the "fringe" claims are going to be included, it could largely be remedied by establishing a consistently clear division between "here is my summary of the interview/paper/the results presented" and "here are my thoughts about how this might theoretically connect to all of the other stuff (plausible or no) that we've heard others talking about in the past." This is particularly important as, for many pwME and especially those in the US, HealthRising is their first real exposure to ME/CFS research and is thus highly likely to inform their understanding of the current state of knowledge (or lack thereof).
 
Last edited:
Trish said:
I find Cort's articles impossible to guage, as he has a tendency to report some research findings probably fairly accurately, then extrapolate wildly in an apparent effort to connect a single research finding to loads of unevidenced and fringe claims and treatments.

Until the research is published or a video of the talk made available, we have no way of knowing what in this article is direct from the research and what is only in Cort's imagination. I think that is very unhelpful.
Click to expand...
Generally agree, but this one stood out. It sort of makes sense. I am big believer in focusing on the ME brain, and this seems like a good lead that could tie together seemingly disparate clues.
 
What about all the stuff about Perrin and spinal stuff? I agree the first bit about what the researchers report finding is interesting and worth following up, but I can't believe the scientists who analysed the CSF made all the dubious sounding links Cort did.
 
One problem of course is that the 'stress' associated with having a lumbar puncture might be rather different for someone with ME/CFS and for a control. I don't know if there were controls but presumably there were. Were they normal people who for some weird reason volunteered to have a lumbar puncture (no way José for me) or people with other diseases?
 
Interesting. I did 3-day urine tests to evaluate my normetanephrine levels for my PoTS. I thought my levels would be high, but they were actually below the lower limit of normal.
Whenever I take any kind of stimulant, I get an inappropriate nervous system response with reflex tachycardia. At that time, my ME/CFS wasn’t even severe… I could go out, walk for an hour, drive my car. I wasn’t bedridden like I am now.
I can’t wait to read the study.
 
Could a dysfunctional norepinephrine pathway lead to post-exertional malaise?

International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (IACFS/ME)
369 followers


September 29, 2025


Share quote
By Fred Friedberg, PhD, IACFS/ME President
www.linkedin.com

Could a dysfunctional norepinephrine pathway lead to post-exertional malaise?

By Fred Friedberg, PhD, IACFS/ME President **FIGURE 1. In response to stress, the hypothalamus (H) releases the corticotrophin releasing factor (CRF) into the anterior pituitary (P), causing the release of adrenocorticotropic hormone (ACTH) into the blood flow.
www.linkedin.com www.linkedin.com
 
Haven't been following in detail but the claim by Cort that this has not been done before is wrong - in the 1990s there was more than one study of monoamine metabolites in CSF. For example Demitrack et al (link) quantified 5-HIAA, HVA & MHPG (metabolites of serotonin, dopamine and noradrenaline) in CSF using HPLC.

If anyone wanted to dig up the others searching PubMed for something like

"chronic fatigue syndrome" AND ("5-HIAA" OR "5-hydroxyindoleacetic acid")

would probably do it. I'm sure I've seen two or three such studies in the past.
 

My Reflections on the 2025 IACFSME Conference​

by Lucinda Bateman, MD | Nov 10, 2025 | BHC News, Long COVID, ME/CFS
batemanhornecenter.org

My Reflections on the 2025 IACFSME Conference

From October 22 through October 25, I attended the 2025 IACFSME 17th Research and Clinical Conference (International Association for Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis)…
batemanhornecenter.org batemanhornecenter.org

Has minimal new information.

“Sadly, several scheduled speakers from federal agencies such as the CDC and NINDS, were absent due to the government shutdown, leaving gaps in the schedule filled in bravely by others using their slides or publication references the best they could.”
Sad to see this though of course very minor compared what employees and some service users have had to go through.
 
You must log in or register to reply here.
Back
Top Bottom