Nutrition Review: Krebs cycle mentioning cfs

https://nutritionreview.org/2013/04/krebs-cycle-intermediates/

 

Chronic Fatigue Syndrome (CFS) represents a condition of debilitating fatigue. Some neurological symptoms of CFS are poor attention, memory loss, lack of concentration and depression. An underlying cause of CFS may be an impairment in the production of mitochondrial adenosine triphosphate (ATP), the fundamental cellular energy source. Studies have found that CFS patients have elevated blood levels of lactate, indicating suboptimal aerobic ATP production that can lead to fatigue and muscle aches.

Studies have shown administering specific Krebs’ cycle amino acid precursors and intermediates to stimulate energy production significantly reduce symptoms of CFS. Therefore supplying a complete range of Krebs’ cycle factors and lactic acid-buffering agents may be of great benefit to the sufferers of CFS. (14,15)

...

Summary
The Krebs’ cycle is an eloquent and essential system designed to generate large amounts of cellular energy required for life. Disruption of the Krebs’ cycle, whether caused by deficiencies in energy substrates, acquired or inherited disease states, or physical stress, leads to an inhibition of normal energy production and contributes to a wide range of metabolic disturbances and symptoms.

The use of supplemental Krebs’ cycle acids and anti-fatigue buffers can assist in the management of mitochondrial energy substrates and increase cellular energy production. Such a nutritional approach can be of benefit to athletes, anyone who is aging, as well as those suffering from metabolic disturbances caused by inherited mitochondrial diseases or acquired diseases, such as Alzheimer’s disease and Chronic Fatigue Syndrome (CFS).

 

Nutrition Review's presentation of itself:
A news site about health science, human physiology, and nutrition, with a focus on alternative medicine and life extension.

 

It's unfortunate that Rich Van Konynenburg is no longer with us. He was sure that the kreb's cycle was involved in ME/CFS and he was very involved in the research at the time of his death.