Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation, 2019, Crabtree et al

Interesting. There was one exertion study on CFS-patients where they measured high levels of NO metabolites, although I can't remember seeing this repeated in other studies.

From: https://www.liebertpub.com/doi/10.1089/jwh.2008.1255#B7 Couldn't find it at scihub unfortunately. Also I have no idea if it's eNOS or iNOS.

 

That depends what the body uses it for It can regulate different things in the body. In this case it mentions how it can induce a pro-inflammatory state, which would be useful depending if you need the immune system acting up. It's a vasodilator, so it can increase bloodflow to tissues, helpful when there's an increased need for oxygen and/or other nutrients or if the tissue needs to be cleared of some metabolite. If you frequently have low blood-pressure, more vasodilation might make it worse. As it briefly mentions in the summary-section Andy posted, it can also decrease energy production, in the full paper they mention yet another way it can do this.

I probably should wait to post this until my brain is a bit less fogged, but the main idea is it depends. I wouldn't want too much of it for no reason, though.