Newly discovered trigger for major depression opens new possibilities for treatments

Discussion in 'Other health news and research' started by Sly Saint, Apr 27, 2023.

  1. Sly Saint

    Sly Saint Senior Member (Voting Rights)

    Messages:
    9,638
    Location:
    UK
    Date:
    March 30, 2023
    Source:
    University of Florida
    Summary:
    The simple amino acid glycine looks to be a previously unknown contributor to depression.

    rest of article here
    Newly discovered trigger for major depression opens new possibilities for treatments -- ScienceDaily

    research paper
    Orphan receptor GPR158 serves as a metabotropic glycine receptor: mGlyR


    paywalled
    Orphan receptor GPR158 serves as a metabotropic glycine receptor: mGlyR | Science
     
  2. Creekside

    Creekside Senior Member (Voting Rights)

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    1,069
    More confirmation on how little is known about how the body works. ME could involve some similar still-undiscovered mechanism, possibly involving highly localized (won't show on blood or CSF tests) concentrations among only a few cells in the brain.

    Okay, that thought alone is a trigger for major depression. :(
     
    Peter Trewhitt, bobbler, Sean and 4 others like this.
  3. Wonko

    Wonko Senior Member (Voting Rights)

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    Location:
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    Lots of science, lots of work, all to avoid doing anything to change the system which might make life less depressing for the masses.

    It's not our fault, it's not the systems fault, it's this little amino acids fault.
     
    Peter Trewhitt, Sean, RedFox and 5 others like this.
  4. boolybooly

    boolybooly Senior Member (Voting Rights)

    Messages:
    539
    Glycine is a ubiquitous AA in food and is considered by many a mood enhancer !? It is not likely to be causing depression.

    This mechanism probably evolved to function as a food consumption related behavioural deactivation feedback loop which makes well fed people relax or even switch to non foraging related behaviours, like socialising etc.

    If you suppress this feedback loop pharmacologically, I would bet people will eat more, become more neurotic and less able to relax and sleep properly, maybe even less sociable.

    I dont think chronically stressed mice represents a valid model for depression either.

    The molecular mechanism may be real but associating it with depression is IMHO unjustified. However depression is where the money is... some people will say anything to get a research grant.
     
    Last edited: Apr 27, 2023
  5. Solstice

    Solstice Senior Member (Voting Rights)

    Messages:
    1,200
    Why shouldn't we do both? Sure the way society is set up can make one depressed, I see my nieces and nephews go to schools that are increasingly akin to workplaces and they loathe the experience. This vacation time is the first I've seen them truly happy for weeks. But if there are defects in our body or in our brains that can cause depression we should find those out too and try to cure it. How can finding out more about our bodies be a negative?
     
    Peter Trewhitt likes this.

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