New MS Drug Approved — Ofatumumab is first self-administered, targeted B-cell treatment for relapsing MS

Jaybee00 · Aug 21, 2020

Another drug for MS, still nothing for MECFS.

https://www.medpagetoday.com/neurology/multiplesclerosis/88195

Jaybee00 · Aug 21, 2020

List of drugs for MS https://www.nationalmssociety.org/Treating-MS/Medications

Modifying the disease course
The following US Food and Drug Administration (FDA) approved disease modifying therapies for MS have been found through clinical trials to reduce the number of relapses, delay progression of disability, and limit new disease activity (as seen on MRI).

Injectable medications

Avonex (interferon beta-1a)

Betaseron (interferon beta-1b)

Copaxone (glatiramer acetate)

Extavia (interferon beta-1b)

Glatiramer Acetate Injection (glatiramer acetate -generic equivalent of Copaxone 20 mg and 40 mg doses)

Glatopa (glatiramer acetate - generic equivalent of Copaxone 20mg and 40mg doses)

Kesimpta® (ofatumumab)

Plegridy (peginterferon beta-1a)

Rebif (interferon beta-1a)

Oral medications

Aubagio (teriflunomide)

Bafiertam (monomethyl fumarate)

Gilenya (fingolimod)

Mavenclad (cladribine)

Mayzent (siponimod)

Tecfidera (dimethyl fumarate)

Vumerity (diroximel fumarate)

Zeposia (ozanimod)

Infused medications

Lemtrada (alemtuzumab)

Novantrone (mitoxantrone)

Ocrevus (ocrelizumab)

Tysabri (natalizumab)

Following the treatment plan that you and your healthcare provider have established is the best possible strategy for managing your MS:

Early and ongoing treatment with disease-modifying therapy is supported by the MS Coalition which includes the National MS Society. This evidence-based Consensus on Disease-Modifying Therapies (.pdf) may be useful when discussing treatment options with your healthcare provider and advocating with insurers for access and coverage.

The American Academy of Neurology (AAN) has developed guidelines for starting, switching and stopping disease modifying therapies for adults with clinically isolated syndrome, relapsing-remitting MS and progressive forms of MS. The National MS Society and Multiple Sclerosis Association of America has endorsed these guidelines.

Adhering to your disease-modifying medication is a key element of treatment effectiveness.

For help in managing the costs of these medications, read about the patient assistance programs offered by the pharmaceutical companies.

Under certain circumstances, some healthcare providers may use medications to treat MS that have FDA approval for other diseases -- also called "off-label" use. Over the past few decades, several medications have been used off-label in MS.
Managing relapses
MS relapses are caused by inflammation in the central nervous system that damages the myelin coating around nerve fibers. This damage slows or disrupts the transmission of nerve impulses and causes the symptoms of MS. Most relapses will gradually resolve without treatment.

For severe relapses (involving loss of vision, severe weakness or poor balance, for example), which interfere with a person’s mobility, safety or overall ability to function, your healthcare provider may recommend treatment with high dose oral or intravenous corticosteroids. Corticosteroids do not have any long-term benefit on the disease.

Medication options include:

High-dose intravenous Solu-Medrol® (methylprednisolone)

High-dose oral Deltasone® (prednisone)

H.P. Acthar Gel (ACTH)

Managing symptoms
A wide variety of medications are used to help manage the symptoms of MS. Below are common symptoms of MS and the medications used to treat those symptoms.

Bladder Problems
Dysfunction

Botox (onabotulinumtoxin A)

DDAVP Nasal Spray (desmopressin)

Detrol (tolterodine)

Ditropan (oxybutynin), Ditropan XL

Enablex (darifenacin)

Flomax (tamsulosin)

Prazosin

Myrbetriq (mirabegron)

Oxytrol (oxybutynin)

Tofranil (imipramine)

Vesicare (solifenacin succinate)

Infection

Bactrim; Septra (sulfamethoxazole)

Cipro (ciprofloxacin)

Levaquin (levofloxacin)

Macrodantim (nitrofurantoin)

Hiprex (methenamine)

Pyridium (phenazopyridine)

Bowel Dysfunction

Colace (docusate)

Dulcolax (bisacodyl)

Enemeez (docusate stool softener laxative)

Fleet Enema (sodium phosphate)

Mineral Oil

Metamucil (psyllium hydrophilic musilloid)

Phillips Milk of Magnesia (magnesium hydroxide)

Sani-Supp suppository (gylcerin)

Depression

Celexa (citalopram)

Cymbalta (duloxetine hydrochloride)

Effexor (velafaxine)

Paxil (paroxetine)

Prozac (fluoxetine)

Wellbutrin (bupropion)

Zoloft (sertraline)

Dizziness and Vertigo

Antivert (meclizine)

Emotional Changes

Nuedexta (dextromethorphan + quinidine)

Fatigue

Adderall (dextroamphetamine and amphetamine)

Amantadine

Provigil (modafinil)

Prozac (fluoxetine)

Ritalin (methylphenidate)

Itching

Vistaril (hydroxyzine)

Pain

Cymbalta (duloxetine)

Effexor (venlafaxine)

Elavil (amitriptyline)

Lamictal (lamotrigine)

Lyrica (pregabalin)

Neurontin (gabapentin)

Pamelor; Aventyl (nortriptyline)

Tegetrol (carbamazepine)

Trileptal (oxcarbazepine)

Sexual Problems

Cialis (tadalafil)

Levitra (vardenafil)

MUSE (alprostadil)

Prostin VR (alprostadil)

Stendra (avanafil)

Viagra (sildenafil)

Spasticity

Baclofen

Botox (onabotulinumtoxin A)

Dantrium (dantrolene)

Klonopin (clonazepam)

Valium (diazepam)

Zanaflex (tizanidine)

Tremors

Laniazid - Nydrazid (isoniazid)

Klonopin (clonazepam)

Walking (Gait) Difficulties

Ampyra (dalfampridine)

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New MS Drug Approved — Ofatumumab is first self-administered, targeted B-cell treatment for relapsing MS

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New MS Drug Approved — Ofatumumab is first self-administered, targeted B-cell treatment for relapsing MS

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