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Neuropilin-1 is a host factor for SARS-CoV-2 infection

Discussion in 'Epidemics (including Covid-19, not Long Covid)' started by Snow Leopard, Jun 22, 2020.

  1. Snow Leopard

    Snow Leopard Senior Member (Voting Rights)

    Messages:
    3,714
    Location:
    Australia
    Neuropilin-1 is a host factor for SARS-CoV-2 infection
    James L. Daly, Boris Simonetti, Carlos Antón-Plágaro, Maia Kavanagh Williamson, Deborah K. Shoemark, Lorena Simón-Gracia, Katja Klein, Michael Bauer, Reka Hollandi, Urs F. Greber, Peter Horvath, Richard B. Sessions, Ari Helenius, Julian A. Hiscox, Tambet Teesalu, David A. Matthews, Andrew D. Davidson, Peter J. Cullen, Yohei Yamauchi

    https://www.biorxiv.org/content/10.1101/2020.06.05.134114v1

    I must admit I was surprised to see this as I have been recently investigating Neuropilins since they have been shown to be cellular entry receptors for Epstein Barr Virus and Cytomegalovirus in epithelial cells. (anyone thinking "that's interesting" right about now?)

    https://www.ncbi.nlm.nih.gov/pubmed/25670642
    https://www.ncbi.nlm.nih.gov/pubmed/31439151
    https://pubmed.ncbi.nlm.nih.gov/30057110/
    See also:
    The role of growth factor receptors in viral infections: An opportunity for drug repurposing against emerging viral diseases such as COVID-19?
    https://pubmed.ncbi.nlm.nih.gov/32395702/
     
    Last edited: Jun 22, 2020
  2. Snow Leopard

    Snow Leopard Senior Member (Voting Rights)

    Messages:
    3,714
    Location:
    Australia
    Part 2:
    Integrins are also common viral entry points (including herpesviruses and picornaviruses, Q fever, Ross River virus etc).

    SARS‐COV‐2 and infectivity: Possible increase in infectivity associated to integrin motif expression
    https://onlinelibrary.wiley.com/doi/10.1002/jmv.25831

    A potential role for integrins in host cell entry by SARS-CoV-2
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114098/

    The Integrin Binding Peptide, ATN-161, as a Novel Therapy for SARS-CoV-2 Infection
    https://www.biorxiv.org/content/10.1101/2020.06.15.153387v1 (hypothesized α5β1integrin-based mechanism)

    An Evolutionary RGD Motif in the Spike Protein of SARS-CoV-2 may Serve as a Potential High Risk Factor for Virus Infection?
    https://www.preprints.org/manuscript/202002.0447/v1

    Short linear motif candidates in the cell entry system used by SARS-CoV-2 and their potential therapeutic implications
    https://arxiv.org/ftp/arxiv/papers/2004/2004.10274.pdf
     

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