Neuropilin-1 is a host factor for SARS-CoV-2 infection

Neuropilin-1 is a host factor for SARS-CoV-2 infection
James L. Daly, Boris Simonetti, Carlos Antón-Plágaro, Maia Kavanagh Williamson, Deborah K. Shoemark, Lorena Simón-Gracia, Katja Klein, Michael Bauer, Reka Hollandi, Urs F. Greber, Peter Horvath, Richard B. Sessions, Ari Helenius, Julian A. Hiscox, Tambet Teesalu, David A. Matthews, Andrew D. Davidson, Peter J. Cullen, Yohei Yamauchi

https://www.biorxiv.org/content/10.1101/2020.06.05.134114v1

I must admit I was surprised to see this as I have been recently investigating Neuropilins since they have been shown to be cellular entry receptors for Epstein Barr Virus and Cytomegalovirus in epithelial cells. (anyone thinking "that's interesting" right about now?)

https://www.ncbi.nlm.nih.gov/pubmed/25670642
https://www.ncbi.nlm.nih.gov/pubmed/31439151
https://pubmed.ncbi.nlm.nih.gov/30057110/
See also:
The role of growth factor receptors in viral infections: An opportunity for drug repurposing against emerging viral diseases such as COVID-19?
https://pubmed.ncbi.nlm.nih.gov/32395702/

 

Part 2:
Integrins are also common viral entry points (including herpesviruses and picornaviruses, Q fever, Ross River virus etc).

SARS‐COV‐2 and infectivity: Possible increase in infectivity associated to integrin motif expression
https://onlinelibrary.wiley.com/doi/10.1002/jmv.25831

A potential role for integrins in host cell entry by SARS-CoV-2
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114098/

The Integrin Binding Peptide, ATN-161, as a Novel Therapy for SARS-CoV-2 Infection
https://www.biorxiv.org/content/10.1101/2020.06.15.153387v1 (hypothesized α5β1integrin-based mechanism)

An Evolutionary RGD Motif in the Spike Protein of SARS-CoV-2 may Serve as a Potential High Risk Factor for Virus Infection?
https://www.preprints.org/manuscript/202002.0447/v1

Short linear motif candidates in the cell entry system used by SARS-CoV-2 and their potential therapeutic implications
https://arxiv.org/ftp/arxiv/papers/2004/2004.10274.pdf