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Neurons Exchange Virus-like Capsules

Discussion in 'Health News and Research unrelated to ME/CFS' started by Forbin, Jan 16, 2018.

  1. Forbin

    Forbin Senior Member (Voting Rights)

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    This is an interesting article. Brain neurons are exchanging RNA molecules using HIV-shaped (icosahedral) capsules. It seems like it may have something to do with learning and the formation of long-term memories.
     
    Allele, Barry, lansbergen and 2 others like this.
  2. lansbergen

    lansbergen Senior Member (Voting Rights)

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    Retrovirus again

    https://www.ncbi.nlm.nih.gov/pubmed/293289
    Cell. 2018 Jan 11;172(1-2):275-288.e18. doi: 10.1016/j.cell.2017.12.024.
    The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer.
    Pastuzyn ED1, Day CE1, Kearns RB1, Kyrke-Smith M1, Taibi AV1, McCormick J2, Yoder N1, Belnap DM3, Erlendsson S4, Morado DR5, Briggs JAG5, Feschotte C2, Shepherd JD6.

    https://www.ncbi.nlm.nih.gov/pubmed/29328915
    Cell. 2018 Jan 11;172(1-2):275-288.e18. doi: 10.1016/j.cell.2017.12.024.
    The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer.
     
    Allele likes this.
  3. lansbergen

    lansbergen Senior Member (Voting Rights)

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    Structural basis of arc binding to synaptic proteins: implications for cognitive disease.

    https://www.ncbi.nlm.nih.gov/pubmed/258646

    Arc N-lobe binding is inhibited by small chemicals suggesting Arc's synaptic action may be druggable
     
    Allele and Wonko like this.

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