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Neocortex saves energy by reducing coding precision during food scarcity, 2021, Zahid Padamsey

Discussion in 'Other health news and research' started by CRG, Nov 9, 2021.

  1. CRG

    CRG Senior Member (Voting Rights)

    Neocortex saves energy by reducing coding precision during food scarcity
    Zahid Padamsey, Danai Katsanevaki, Nathalie Dupuy, Nathalie L Rochefort

    Information processing is energetically expensive. In the mammalian brain, it is unclear how information coding and energy use are regulated during food scarcity. Using whole-cell recordings and two-photon imaging in layer 2/3 mouse visual cortex, we found that food restriction reduced AMPA receptor conductance, reducing synaptic ATP use by 29%. Neuronal excitability was nonetheless preserved by a compensatory increase in input resistance and a depolarized resting potential. Consequently, neurons spiked at similar rates as controls but spent less ATP on underlying excitatory currents. This energy-saving strategy had a cost because it amplified the variability of visually-evoked subthreshold responses, leading to a 32% broadening of orientation tuning and impaired fine visual discrimination. This reduction in coding precision was associated with reduced levels of the fat mass-regulated hormone leptin and was restored by exogenous leptin supplementation. Our findings reveal that metabolic state dynamically regulates the energy spent on coding precision in neocortex.

    Keywords: calorie restriction; hunger and satiety; in vivo ATP imaging; in vivo calcium imaging; in vivo electrophysiology; leptin; mouse primary visual cortex; orientation tuning; spike rate homeostasis; trial-to-trial variability.

    Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

    Conflict of interest statement

    Declaration of interests The authors declare no competing interests


    This study is in mice - but might be of interest if calorie restriction is a proxy for otherwise reduced energy availability for the mammalian brain.
    Last edited by a moderator: Nov 9, 2021
    obeat, shak8, Wonko and 4 others like this.
  2. Jonathan Edwards

    Jonathan Edwards Senior Member (Voting Rights)

    London, UK
    This must be why people who cannot find a kebab shop at 2.00 in the morning tend to bump in to lamp-posts?
  3. hibiscuswahine

    hibiscuswahine Senior Member (Voting Rights)

    Clinically, have seen a few people’s mental health conditions significantly deteriorate after starting restrictive diets.
    Samuel, Ash, shak8 and 4 others like this.
  4. FMMM1

    FMMM1 Senior Member (Voting Rights)

    Might this explain some of the statements/reactions from members of the Royal Colleges to the new guideline?
    CRG, shak8, alktipping and 2 others like this.

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