I wrote a bit about my thyroid issues in my Intro, but as it's looming large in my mind at the moment, I thought i would expand here in case anyone has any gems of wisdom to help. I did write a bit from time to time in 'the other place' but still feel things are not completely clear or resolved in my mind as to whether I do have ME or whether it's 'just' the thyroid/adrenal issue that is not well managed. There do seem so many overlaps. I was diagnosed with underactive thyroid over 20 years ago, but when I slowly became ill during my menopause beginning about 15 years ago with frequent viruses, I did not link it with the thyroid as I was told that my numbers were fine. Some years later I got ill enough to get the ME/CFS diagnosis with more typical symptoms related to that. It was many more years before I began to investigate the thyroid connection and by then I had been on Thyroxine/T4 for 17 years. Eventually I ended up on Liothyronine/T3 for nearly 5 years until our NHS began to check out everyone on it, and I was diagnosed with osteoporosis, and the T3 only was blamed of course. Since July I have been slowly had the T3 reduced and the T4 put back in and increased. I thought it was worth a try as I had never really been on T4/T3 for very long. I thought maybe I would be OK...... How wrong I turned out to be. I can't say I was CURED on T3 only, but I had certainly got a reasonable amount of energy and I had slowly worked on my various other symptoms and improved matters with various approaches. Since July within weeks my viruses have returned big time, with 4 colds in 2 months in July/Aug (ie summer) and since then at least a cold a month, with the current one for 3 weeks now. When the T4 reached 75mcg and the T3 down to 20mcg, I had 4 migraines in a week (having reduced the level of these hugely by using natural progesterone as I had migraines, but not this often normally). I wrote to the Endo and the Endo's nurse who I had been forced to see every 6 weeks. She was awful - just like a robot, with no interest in my declining health as long as she did her job of getting me on the doses she was told to get me to. I even showed her the evidence of immunoglobulin tests I had done at the start and 6 weeks on and the decline was there to see (IgA below range and lower, and IgG dropped below range) to be told 'there are a lot of colds about....' (in July?). In reply to my letter a few weeks ago to tell them that I was dropping back to the previous dose of 50 T4 and 25 T3, I had a copy of a letter sent to my GP telling her that they were discharging me into her care. I now feel that once again I have to take my health into my own hands because no one really knows the answers even though they believe that they do know them. I was told that a suppressed TSH would have contributed towards my osteoporosis even though patient groups totally disagree with this and believe that the patient should be treated and not the numbers. At the end of the day I feel I have to take a risk if I am to feel reasonably well and will have to treat myself as many thyroid patients now do and support each other. It's not ideal but I cannot go on like I have been doing. I may end up having to buy my own thyroid medication if things go on as they are doing in the UK with T3 being stopped in many places. At the moment I am officially allowed 25mcg (so I am one of the lucky ones) but I don't believe it's enough for me. I was previously on 50mcg T3 at one time and did not have adverse symptoms while I was on it. Hopefully this time I can stay on some T4 even if it's a smaller amount, so will have to see how I do as I begin to adjust my doses again. I am also supporting my adrenals as my cortisol tests in the past (3 in 4 years) showed low cortisol, by using licorice, ashwaghanda, natural progesterone and now I am adding in some Adrenal Cortex too to see if that helps. Sorry, long post, and well done if you read it all.....long story unfortunately and this is the shorter version.