Mij
Senior Member (Voting Rights)
Abstract
Objective
To assess whether muscle power (force times velocity) outperforms strength as a risk indicator and predictor of mortality.
Participants and Methods
Anthropometric, clinical and vital status, muscle power, and strength data were assessed in 3889 individuals aged 46 to 75 years (2636 [67.8%] men) who were participants in the CLINIMEX Exercise prospective cohort between February 13, 2001, and October 31, 2022. Study participants were stratified by sex and categorized into 4 groups according to the distribution of the results of relative muscle power and strength (adjusted for body weight) measured, respectively, by handgrip and upper row movement tests.
Results
Death rates were 14.2% (373 of 2636) and 8.9% (111 of 1253) for men and women, respectively, during a median (IQR) follow-up of 10.8 years (6.7 to 15.5 years). In multivariable Cox proportional hazards regression analyses, the hazard ratios (95% CIs) for mortality comparing the lowest vs highest categories of relative muscle power were 5.88 (2.28 to 15.17; P<.001) and 6.90 (1.61 to 29.58; P=.009) for men and women, respectively. The corresponding hazard ratios (95% CIs) for relative strength were 1.62 (0.89 to 2.96; P=.11) and 1.71 (0.61 to 4.80; P=.31), respectively. Sex-specific results of risk prediction analyses revealed that improvements in C index provided by relative power over relative strength were 0.0110 (95% CI, 0.0039 to 0.0182) in men and 0.0112 (95% CI, −0.0040 to 0.0265) in women.
Conclusion
In this large prospective study, relative muscle power was a stronger predictor of mortality than relative strength in middle-aged and older men and women. Evaluating and training muscle power could be of clinical and practical relevance.
LINK
Objective
To assess whether muscle power (force times velocity) outperforms strength as a risk indicator and predictor of mortality.
Participants and Methods
Anthropometric, clinical and vital status, muscle power, and strength data were assessed in 3889 individuals aged 46 to 75 years (2636 [67.8%] men) who were participants in the CLINIMEX Exercise prospective cohort between February 13, 2001, and October 31, 2022. Study participants were stratified by sex and categorized into 4 groups according to the distribution of the results of relative muscle power and strength (adjusted for body weight) measured, respectively, by handgrip and upper row movement tests.
Results
Death rates were 14.2% (373 of 2636) and 8.9% (111 of 1253) for men and women, respectively, during a median (IQR) follow-up of 10.8 years (6.7 to 15.5 years). In multivariable Cox proportional hazards regression analyses, the hazard ratios (95% CIs) for mortality comparing the lowest vs highest categories of relative muscle power were 5.88 (2.28 to 15.17; P<.001) and 6.90 (1.61 to 29.58; P=.009) for men and women, respectively. The corresponding hazard ratios (95% CIs) for relative strength were 1.62 (0.89 to 2.96; P=.11) and 1.71 (0.61 to 4.80; P=.31), respectively. Sex-specific results of risk prediction analyses revealed that improvements in C index provided by relative power over relative strength were 0.0110 (95% CI, 0.0039 to 0.0182) in men and 0.0112 (95% CI, −0.0040 to 0.0265) in women.
Conclusion
In this large prospective study, relative muscle power was a stronger predictor of mortality than relative strength in middle-aged and older men and women. Evaluating and training muscle power could be of clinical and practical relevance.
LINK