Hello - I've been pretty open and public about my illness, and I've had something come up that I'd like to hear from the community about. About six months after I got my sudden fever, I started rapidly losing weight. I went from 185 pounds down to 155. I'm 6' tall, so 155 is underweight. I lost muscle, and I have slowly continued to lose muscle over the past five years. I have indentations in my skin in places that I shouldn't. I've long wondered if this is part of my ME or if it's a comorbidity. Earlier this year, I had a muscle biopsy, and the pathologists reading it saw some odd things. I'd be curious if folks on the forum who have had biopsies or know about how to interpret them had any input on this. The main findings are: "This biopsy shows a mild, chronic necrotizing myopathy with perimysial and endomysial perivascular inflammation and diffusely upregulated MHC-1 staining. Differential diagnosis includes inflammatory myopathies such as dermatomyositis and muscular dystrophies with inflammation. The prominent dystrophic features including fiber size variability, numerous split fibers, and many fibers with multiple internalized nuclei suggests the possibility of myotonic dystrophy, though clinical correlation is suggested." A .pdf of the biopsy report from Hopkins is at this link: I've had a consult with a muscular dystrophy specialist, and my genetics are being run against all the known muscular dystrophy SNPs and mutations by NIH. The specialist is pretty sure I wouldn't qualify for any known muscular dystrophy. The NIH intramural study I'm enrolled in is looking at muscle biopsies of other patients, so they will eventually be able to compare my results to others. But I'm curious to know if anything in this report has been seen in ME before. Thanks.