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Multidisciplinary approach to functional somatic syndromes: study protocol for a population-based prospective cohort study, 2022, Adibi et al

Discussion in 'Psychosomatic research - ME/CFS and Long Covid' started by Andy, Jul 3, 2022.

  1. Andy

    Andy Committee Member

    Hampshire, UK


    Isfahan functional disorders (ISFUN) cohort study aims to describe the interplay of genetic and environmental factors in shaping the characteristics of functional somatic syndromes (FSS). This study is primarily intended to investigate the epidemiology, risk factors, course and prognosis of FSSs in a sample of adult Iranian population. The other aim is to develop a new delimitation of FSSs based on an integrated multidisciplinary approach comprising of phenotypic and multiomics data.

    Methods and analysis

    ISFUN is a population-based prospective cohort study designed to follow a population of randomly selected seemingly healthy adults (18–65 years) through annual visits during a 4-year observation period. Structured questionnaires are used for data collection and clinical assessment of the participants. Questionnaire-based diagnosis of FSSs are validated in a medical interview. Human DNA genotyping, microbial amplicon sequencing and urine analysis is under progress for genomics, microbiota and metabolomics profiling, respectively. Enrolment began in September 2017, and study completion is expected in 2022. A total number of 1943 participants were initially recruited.

    Ethics and dissemination

    Ethical approval for data collection was granted by the National Research Ethics Committee of the Iranian Ministry of Health and Medical Education and the Research Ethics Committee of Isfahan University of Medical Sciences (IR.MUI.REC.1395.1.149). Following the description of the study procedure, we obtained written informed consent from all study participants. Study findings will be disseminated through peer-reviewed publications and presentations at scientific meetings.

    Open access, https://bmjopen.bmj.com/content/12/7/e048941
    Peter Trewhitt and Trish like this.
  2. MEMarge

    MEMarge Senior Member (Voting Rights)

    Looks like another huge waste of time and money.

    Surely Iranians would benefit from resources spent in other ways.
    Sean, alktipping and Peter Trewhitt like this.

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