Jonathan Edwards
Senior Member (Voting Rights)
Why is this worth looking at in PwME whose ME didn't follow Covid? Isn't all this microcirculation stuff likely to be quite Covid-specific?
No, there have been a range of suggestions for vascular change sin ME/CFS. Some clinicians claim there are colour changes in hands and feet and several members have reported that. There have been studies suggesting changes in red cell deformability. The autonomic nervous system is implicated, which controls vascular calibre, if less so capillaries. And so on. A negative result is quite likely but that would suggest that ME/CFS can occur quite independently of any microvascular change, which might be an important lesson for Long Covid researchers focused on vessels and coagulation. And so on.
It is going back to the point that there are so few clues in ME/CFS anything like this is probably worth checking out. And since it is unbelievably low tech why not?