https://www.pnas.org/content/early/2020/06/16/2002250117 popular article here https://newsroom.uw.edu/news/study-yields-clues-how-drug-may-boost-aged-mitochondria
Much too technical for my understanding but there do seem to be a few interesting points here (IIRC SS31 was the molecule that had the best effect in the "something in the blood" nano-needle tests). SS31 has no effect on mitochondrial function in young, healthy mitochondria, only on old or sick ones - hmm, what does that imply about our mitos? SS31 improves function of complex V - the very complex which may not be working efficiently in ME. SS31 may affect 2-OG signalling, 2-OG being thought a sort of master regulator metabolite affecting ATP synthase and target of rapamycin (TOR) and also being involved in hypoxia signalling - all stuff that keeps turning up in ME studies. SS31 interacts with cardiolipin - antibodies against cardiolipin have been found in ME. I've no idea of the true relevance of any of this.