Mite in the gut??

[Inara]

Hey everybody,

does anybody know if something like mite in the gut exist? I can't find anything and speculate it doesn't exist.

It's a passage in an official document by the DRV (DWP in UK), and I'm puzzled. Maybe it's just an error from their side (which I can use ).

 

[Trish]

A quick google search gave me this on Pub Med:
Presence of commensal house dust mite allergen in human gastrointestinal tract: a potential contributor to intestinal barrier dysfunction.

 

[Inara]

Wow, Trish, thanks.

This is about normal dust mites. In the gut?? How does that work? Dust mites can survive in the gut??

 

[MSEsperanza]

This is about normal dust mites. In the gut?? How does that work? Dust mites can survive in the gut??

It's not mites, but mites excrements.

They are in the air

almost everywhere.

 

[Inara]

It's not mites, but mites excrements.

They are in the air

almost everywhere.

Ok, had a second look. Thank you. They detected Der p1 in the gut. Der p1 is a part of the excrements of mite? But they say

HDM, a ubiquitous environmental factor, is present in the human gut where it directly affects gut function through its proteolytic activity.

where HDM = house dust mites.
I am sorry, it's still not clear to me. Is it mites in the gut or their excrements/whatever?

 

[Inara]

It's not mites, but mites excrements.

They are in the air

almost everywhere.

Yes, I know, I have an allergy. But the gut connection is new to me.

 

[Invisible Woman]

Is it mites in the gut or their excrements/whatever?

I suspect it might be both the mite and their excrement. Yuck!

It's almost impossible to avoid either and if one if 'em is getting in there then so is the other. Whether both get through the stomach intact is another question.

 

[Inara]

Ahh, so it's dead mites (i.e. "mites protein") and their excrements in the gut? Still, I find that interesting.

 

[hinterland]

Ahh, so it's dead mites (i.e. "mites protein") and their excrements in the gut? Still, I find that interesting.

Interesting and a bit disgusting, haha!

 

[Inara]

Interesting and a bit disgusting, haha!

Actually, now that you say it explicitly, yes.

 

[Hutan]

Presence of commensal house dust mite allergen in human gastrointestinal tract: a potential contributor to intestinal barrier dysfunction.

2016, Tulic et al
That is an interesting paper, thanks Trish.

HDM Der p1 was detected in the human gut. In colonic biopsies from healthy patients, HDM increased epithelial permeability (p<0.001), reduced expression of tight-junction proteins and mucus barrier. These effects were associated with increased tumour necrosis factor (TNF)-α and interleukin (IL)-10 production and were abolished by cysteine-protease inhibitor (p<0.01). HDM effects did not require Th2 immunity. Results were confirmed in vivo in mice. In patients with IBS, HDM further deteriorated gut barrier function, induced TNF-α but failed to induce IL-10 secretion (p<0.001).

CONCLUSIONS:
HDM, a ubiquitous environmental factor, is present in the human gut where it directly affects gut function through its proteolytic activity. HDM may be an important trigger of gut dysfunction and warrants further investigation.