Microvesicles and exosomes in metabolic diseases and inflammation, 2020, Dini et al

[Andy]

Metabolic diseases are based on a dysregulated crosstalk between various cells such as adipocytes, hepatocytes and immune cells. Generally, hormones and metabolites mediate this crosstalk that becomes alterated in metabolic syndrome including obesity and diabetes.

Recently, Extracellular Vesicles (EVs) are emerging as a novel way of cell-to-cell communication and represent an attractive strategy to transfer fundamental informations between the cells through the transport of proteins and nucleic acids. EVs, released in the extracellular space, circulate via the various body fluids and modulate the cellular responses following their interaction with the near and far target cells. Clinical and experimental data support their role as biomarkers and bioeffectors in several diseases includimg also the metabolic syndrome. Despite numerous studies on the role of macrophages in the development of metabolic diseases, to date, there are little informations about the influence of metabolic stress on the EVs produced by macrophages and about the role of the released vesicles in the organism.

Here, we review current understanding about the role of EVs in metabolic diseases, mainly in inflammation status burst. This knowledge may play a relevant role in health monitoring, medical diagnosis and personalized medicine.

Paywall, https://www.sciencedirect.com/science/article/abs/pii/S1359610119301479
Sci hub, https://sci-hub.se/10.1016/j.cytogfr.2019.12.008

 

[Hoopoe]

I wonder if there has been too much focus on the immune system in ME/CFS. As this article says there could be dysfunctional crosstalk between other kinds of cells and with the focus on immune system, that may be why the cause hasn't been found yet.

In particular the dysfunctional crosstalk could be between cells that are involved in recovery from exertion. If some of these cells are overreactive, that could lead to the body reacting to minor exertion in perhaps the same way as it would to extreme overexertion.