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Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines & emotional behavior

Discussion in 'Health News and Research unrelated to ME/CFS' started by Woolie, Dec 14, 2017.

  1. Woolie

    Woolie Senior Member

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    Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines & emotional behavior Miyajima, M., et al.
    Nature Immunology 18, 1342–1352 (2017)
    doi:10.1038/ni.386

    https://www.nature.com/articles/ni.3867

    From the abstract:
    Okay, its mouse science. And these were genetically modified mice, and you can't ever be really sure whether the genetic modification is entirely selective to the thing you think it is (the excessive T cell activation). But kind of interesting nonetheless.
     
    Trish, Valentijn, Andy and 2 others like this.
  2. Jonathan Edwards

    Jonathan Edwards Senior Member (Voting Rights)

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    I doubt the result has anything particular to do with T cells. It shows that a large number of unregulated cells - most typically seen in cancer - eat up nutrients. People have observed cancer patients becoming cachectic for centuries. Many of these engineered mice have huge numbers of the unregulated cells. The MRL/lpr mouse has lymph nodes the size of cashew nuts, which scaled up to human size would weigh many kilograms.
     
    Trish, TrixieStix, Valentijn and 2 others like this.

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