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Metabolic fingerprinting for diagnosis of fibromyalgia and other rheumatologic disorders (2018) Hackshaw et al.

Discussion in 'Fibromyalgia and Connective Tissue Disorders' started by Cheshire, Dec 20, 2018.

  1. Cheshire

    Cheshire Moderator Staff Member

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    (Paragraph breaks are mine)

    Open access: http://www.jbc.org/content/early/2018/12/06/jbc.RA118.005816.long
     
    ahimsa, obeat, Lisa108 and 15 others like this.
  2. shak8

    shak8 Senior Member (Voting Rights)

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    Very interesting! Could they be holding back the identity of specifics because of a possible patent on a diagnostic test kit in the future? Or too soon for that...probably.
     
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  3. Snowdrop

    Snowdrop Senior Member (Voting Rights)

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    From the discussion section of the paper:

    "This study assessed the feasibility of vibrational spectroscopy to differentiate individuals with FM from those with several other rheumatic conditions including RA, SLE, and OA.

    In addition, we wanted to determine if various degrees of severity of FM were biochemically distinguishable from each other using a novel means of rapid detection. Advantages of such a methodology, if developed and honed to reproducibility, would be a capability for identifying specific treatment subsets for FM as well as identifying new targets as differentiated from each other metabolically by spectroscopy (UV-vis, MS, and vibrational).

    The results of the study found a unique Raman spectral signature that clustered all subjects into classes (FM, RA, and SLE) with no misclassifications. The discriminating power was dominated by vibrations of the backbone in proteins and nucleic acids, and also indicated mineral differences in blood as biomarker."

    Does anyone know anything about vibrational spectroscopy? Is this a real thing?

    The methods section seems kinda complicated.
     
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  4. ahimsa

    ahimsa Senior Member (Voting Rights)

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    I don't have any more information, and can't answer the question asked by @Snowdrop - but I thought I'd post a link to a news article about this paper just in it has any helpful information.

    https://www.sciencedaily.com/releases/2019/03/190318084127.htm

    I thought this was a good sign (so many researchers seem to want to skip this step):
    I have two different friends with a Fibromyalgia diagnosis. I'd be interested in whether this study looks promising before I pass on the news to them.
     
  5. leokitten

    leokitten Senior Member (Voting Rights)

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  6. Sly Saint

    Sly Saint Senior Member (Voting Rights)

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    article in Ohio State University news
    Experimental blood test accurately spots fibromyalgia
    Study finds unique ‘molecular signature’ for often-misdiagnosed disease
    https://news.osu.edu/experimental-b...Nqb4CBlYYKx8cShnorR8ihprQv_WmrbJ95vaGqP341VBY
     
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