ME Research UK: Role of Sirt1/NOS axis in vascular and immune homeostasis: a missing piece in the ME/CFS puzzle?

Andy

Andy

Retired committee member
One of the ways the endothelium controls blood flow is through the release of a chemical called nitric oxide. But nitric oxide is a double-edged sword – while it is essential in normal endothelial function (and is also involved in the central nervous system), too much can be damaging and lead to prolonged inflammation.

Dr Westermeier is exploring this complicated relationship in more detail by looking at whether the cellular mechanisms that control nitric oxide production are altered in ME/CFS.

Using blood samples obtained from the UK ME/CFS Biobank, he will assess levels of nitric oxide and the proteins involved in its production (Sirt1, eNOS and Arg1). He will also investigate whether this is altered in endothelial cells that have been exposed to blood plasma from people with ME/CFS.

The researchers hope their findings will throw new light onto the role of these complex mechanisms in ME/CFS, and possibly identify new biomarkers of endothelial dysfunction in the illness.
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http://www.meresearch.org.uk/our-research/sirt1-nos-axis/

 
I often think that I have some sort of inflammation going on, in different body parts. It feels like mild inflammation at least. Maybe it's not the c-reactive protein kind of inflammation. Something is happening there but it's not clear what.

Is there a list of processes that feel like inflammation but aren't considered inflammation in the strict sense?
 
Sarah94 said:
How long will it take to get the results of this?
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A wild guess, a couple of years minimum?

Say, at best, a few months to do the experiments, then six month to a year to analyse the results and write the paper, given that academics have a lot of other responsibilities as well, then a few months to find a journal to accept the submission, a few more months for the paper to be peer reviewed and if necessary the paper amended, then a few more months for the journal to get around to publishing it.
 
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