Hello I see scatterings of conversations around this topic here but couldn't find a single thread which dealt with this overall assertion. That ME is late onset ASD and that PEM and autistic overload may be related. Naviaux seems to be the touch point, but I am asking regarding the overall topic including his thinking, but not just his. It makes experiential sense to me, but recent discussion showed Gulf War Syndrome and ME PEM to be qualitatively similar but neurologically different. It may also just be the result of overlapping Venn diagrams of symptoms, comorbidities and comorbidities of comorbidities. Correlation is not causation, Christmas cards do not cause Christmas. Causation may appear backwards after a few cycles. Or they may merely be correlated with another cause But I'm so curious about the assertion, esp in view of nascent microbiomal evidence re ASD. I'd love to see this idea dissected by people who can say more than me on it. Some subjective narrative: https://www.syndromea.org/2018/10/29/autism-and-chronic-fatigue-syndrome/ Some tentative similarities: Reduced HRV and HF HRV in people with autism: https://www.ncbi.nlm.nih.gov/m/pubmed/30972967/ Autonomic underarousal: https://www.ncbi.nlm.nih.gov/m/pubmed/28006949/ Low cortisol, sleep disruptions and maybe overarousal: https://www.ncbi.nlm.nih.gov/m/pubmed/30896090/ General https://www.omf.ngo/2017/10/19/treating-autism-and-mecfs-could-one-drug-do-both/ Apologies if I missed where a previous thread became more general to this topic.