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[McGarry et al. 2018] Hypoxia, Oxidative Stress and Inflammation

Discussion in 'Health News and Research unrelated to ME/CFS' started by Samuel, Apr 7, 2018.

  1. Samuel

    Samuel Senior Member (Voting Rights)

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    https://www.ncbi.nlm.nih.gov/pubmed/29601945

    > In this adverse microenvironment synovial cells adapt to generate energy and switch their cell metabolism from a resting regulatory state to a highly metabolically active state which allows them to produce essential building blocks to support their proliferation. This metabolic shift results in the accumulation of metabolic intermediates which act as signaling molecules that further dictate the inflammatory response.

    perhaps somebody might find it interesting. did not read. @Jonathan Edwards your field?

    [what metabolic states exist out there? is this a typical discovery? what is the status of the evolutionarily conserved metabolic state hypothesis/es? could this vary by cell type?]
     
    Last edited: Apr 7, 2018
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  2. Trish

    Trish Moderator Staff Member

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    This is a paper about inflammatory arthritis. Here's the abstract, broken up into short sections by me for easy reading.

     
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