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Loss of Transient Receptor Potential Melastatin 3 ion channel function in natural killer cells from CFS/ME (2018) Marshall-Gradisnik et al

Discussion in 'BioMedical ME/CFS Research' started by hixxy, Aug 24, 2018.

  1. hixxy

    hixxy Senior Member (Voting Rights)

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    https://www.ncbi.nlm.nih.gov/pubmed/30134818
    https://molmed.biomedcentral.com/articles/10.1186/s10020-018-0046-1
     
  2. hixxy

    hixxy Senior Member (Voting Rights)

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    I thought this had been posted already but I couldn't find it. Maybe it was just an early announcement I saw.
     
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  3. John Mac

    John Mac Senior Member (Voting Rights)

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    Wonko and adambeyoncelowe like this.
  4. Londinium

    Londinium Senior Member (Voting Rights)

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    Interesting result and clear the NCNED team are still pursuing their calcium theory. However (as the limitations section notes), this had only six patients and six controls so, even though it found statistically significant differences between patients and controls, it is in dire need of replication before drawing too much in the way of conclusions. *If* replicated then it would seem to provide a potential explanation for the reduced NK-cell function that has been reported multiple times in ME/CFS studies.
     

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