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Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease, 2017, Mills, Curtis et al

Discussion in 'Health News and Research unrelated to ME/CFS' started by Andy, Dec 12, 2017.

  1. Andy

    Andy Committee Member

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    Open access at https://www.nature.com/articles/s41467-017-02111-0
     
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  2. Andy

    Andy Committee Member

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    Article based on this paper
    http://neurosciencenews.com/time-autoimmune-disease-8169/
     
  3. Sly Saint

    Sly Saint Senior Member (Voting Rights)

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    watched Horizon last night

    "
    Body Clock: What Makes Us Tick?
    Horizon 2018
    We all have a biological clock ticking away inside us that governs our daily rhythms. This affects our health as much as our diet and whether we exercise. So what can we do to manage this internal clock better?

    To find out, evolutionary biologist Ella Al-Shamahi locks former commando Aldo Kane in an abandoned nuclear bunker with no way of telling the time - for ten days. Monitored around the clock by a team of scientists, he carries out a barrage of tests to uncover exactly what makes our body clock tick.

    Above ground, Ella meets two time-starved couples to test the latest thinking on how we can manage our body clocks better. In trying to improve their sleep, and their lives, she uncovers practical advice that we can all take on board. Studies on shift workers show that regularly disrupting our sleep makes us more at risk of diabetes, heart disease and even cancer. So getting to grips with our biological clock couldn't be more important."

    But the most interesting bit was the interview with one of the original researchers (Professor Jeffrey Hall Chronobiologist) and the explanation of how the Period gene works (21.30), not just in fruit flies but also in humans.

    https://www.bbc.co.uk/iplayer/episode/b0bn5ys4/horizon-2018-9-body-clock-what-makes-us-tick

    for real scientific stuff:
    Circadian rhythms in mitochondrial respiration.
    https://www.ncbi.nlm.nih.gov/pubmed/29378772

    and very complicated stuff:
    PER1 period circadian regulator 1 Homo sapiens (human)
    https://www.ncbi.nlm.nih.gov/gene/5187

    would be interesting to see if there is any real disruption of the circadian clock at the cellular level (as opposed to observing things at different times of the day) in pwME.
     
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