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Long-term Prognosis at 1.5 years after Infection with Wild-type strain of SARS-CoV-2 and Alpha, Delta, as well as Omicron Variants, 2023, Agergaard et

Discussion in 'Long Covid research' started by SNT Gatchaman, Oct 31, 2023.

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  1. SNT Gatchaman

    SNT Gatchaman Senior Member (Voting Rights)

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    Long-term Prognosis at 1.5 years after Infection with Wild-type strain of SARS-CoV-2 and Alpha, Delta, as well as Omicron Variants
    Jane Agergaard; Jesper Damsgaard Gunst; Berit Schiøttz-Christensen; Lars Østergaard; Christian Wejse

    Objectives
    Knowledge is limited on how changing SARS-CoV-2 variants may translate into different characteristics and affect prognosis of patients with long COVID, especially following Omicron variants. We compared long-term prognosis of patients in a Danish Post COVID Clinic infected with wild-type strain, Alpha, Delta, or Omicron variants as well as the pre-Omicron compared to the Omicron period.

    Methods
    At enrollment a Post COVID symptom Questionnaire (PCQ), and standard health scores, were registered, and repeated four times until 1.5 years after infection. PCQ was the primary outcome to assess severity of long COVID, and delta PCQ to assess failure to improve.

    Results
    A total of 806 patients were enrolled. Patients infected with Omicron and Delta variants presented with more severe long COVID (median PCQ 43 in Delta vs 38 in wild-type, P=0.003) and health scores (EQ5D-index was 0.70 in Omicron vs 0.76 in wild-type, P=0.009 and 0.78 pre-Omicron, P=0.006). At 1.5 year after infection patients had no clinically meaningful decline in severity of long COVID, and 57% (245/429) of patients failed to improve 1.5 years after infection, with no differences between variants.

    Conclusions
    More than half of patients referred to a Post COVID Clinic failed to improve in long COVID severity 1.5 years after infection regardless of variants of SARS-CoV-2.


    Link | PDF (International Journal of Infectious Diseases)
     
    SNT Gatchaman, Oct 31, 2023
    #1
    Kitty, Wonko, Trish and 5 others like this.
  2. Hutan

    Hutan Moderator Staff Member

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    Post COVID Clinic at Aarhus University Hospital (AUH)
    There are a lot of typos that make this paper rather difficult to read. e.g.
    (Ref 9 says "The available data suggest that the infection with the Omicron variant results in fewer long-COVID symptoms compared to previous variants" and doesn't contain the word 'fever'."
    I think the International Journal of Infectious Diseases needs to work a bit harder at its editing.

     
    Hutan, Oct 31, 2023
    #2
    Sean, Kitty, Wonko and 5 others like this.
  3. Hutan

    Hutan Moderator Staff Member

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    Location:
    Aotearoa New Zealand
    Worth noting the patients with later variants were seen earlier (median 4 months). That might have affected severity ratings and recovery rates.
    Also, most of the patients were infected during the 'wild-type' period (556/804).
     
    Last edited: Oct 31, 2023
    Hutan, Oct 31, 2023
    #3
    alktipping, Kitty, Wonko and 4 others like this.

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